Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
J Acquir Immune Defic Syndr. 2011 Nov 1;58(3):248-52. doi: 10.1097/QAI.0b013e318228f992.
Most T cell-based HIV-1 vaccine candidates induce responses of limited breadth for reasons that are unclear. We evaluated vaccine-induced T-cell responses in individuals receiving an HIV-1 recombinant adenoviral vaccine. Certain HLA alleles (B27, B57, B35, and B14) are preferentially utilized to mount HIV-specific responses, whereas other alleles (A02 and B07) are rarely utilized (P < 0.001). This preference seems due to 4 following factors individually or in combination: higher affinity of specific peptides to specific HLA alleles; higher avidity of T-cell receptor; HLA and peptide interaction; and/or higher surface expression of certain HLA. Thus, HLA immunodominance plays a substantial role in vaccine-induced T-cell responses.
大多数基于 T 细胞的 HIV-1 疫苗候选物由于原因不明而诱导的反应范围有限。我们评估了接受 HIV-1 重组腺病毒疫苗的个体中疫苗诱导的 T 细胞反应。某些 HLA 等位基因（B27、B57、B35 和 B14）优先用于产生 HIV 特异性反应，而其他等位基因（A02 和 B07）很少被利用（P < 0.001）。这种偏好似乎归因于以下 4 个因素的单独或组合作用：特定肽与特定 HLA 等位基因的亲和力更高；T 细胞受体的高亲和力；HLA 和肽相互作用；和/或某些 HLA 的表面表达更高。因此，HLA 免疫优势在疫苗诱导的 T 细胞反应中起着重要作用。
