网格蛋白在有丝分裂中的新功能
Novel functions of endocytic player clathrin in mitosis.
机构信息
The MOE Key Laboratory of Cell Proliferation and Differentiation and the State Key Laboratory of Bio-membrane and Membrane Biotechnology, College of Life Sciences, Peking University, Beijing 100871, China.
出版信息
Cell Res. 2011 Dec;21(12):1655-61. doi: 10.1038/cr.2011.106. Epub 2011 Jun 28.
Abstract
Clathrin has been widely recognized as a pivotal player in endocytosis, in which several adaptors and accessory proteins are involved. Recent studies suggested that clathrin is also essential for cell division. Here this review mainly focuses on the clathrin-dependent mechanisms involved in spindle assembly and chromosome alignment. In mitosis, clathrin forms a complex with phosphorylated TACC3 to ensure spindle stability and proper chromosome alignment. The clathrin-regulated mechanism in mitosis requires the crosstalk among clathrin, spindle assembly factors (SAFs), Ran-GTP and mitotic kinases. Meanwhile, a coordinated mechanism is required for role transitions of clathrin during endocytosis and mitosis. Taken together, the findings of the multiple functions of clathrin besides endocytosis have expanded our understanding of the basic cellular activities.
摘要
网格蛋白被广泛认为是胞吞作用中的关键参与者，其中涉及几种衔接蛋白和辅助蛋白。最近的研究表明，网格蛋白对于细胞分裂也是必不可少的。本文主要综述了网格蛋白在纺锤体组装和染色体排列中的作用机制。在有丝分裂过程中，网格蛋白与磷酸化的 TACC3 形成复合物，以确保纺锤体的稳定性和染色体的正确排列。有丝分裂中网格蛋白调控机制需要网格蛋白、纺锤体组装因子（SAFs）、Ran-GTP 和有丝分裂激酶之间的相互作用。同时，网格蛋白在胞吞作用和有丝分裂中的作用转换需要协调机制。总之，网格蛋白除了胞吞作用之外的多种功能的发现，扩展了我们对基本细胞活动的理解。
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