CdSe/ZnS 量子点-细胞色素 c 生物缀合物用于选择性的细胞内 O2˙⁻ 传感。
CdSe/ZnS quantum dot-Cytochrome c bioconjugates for selective intracellular O2˙⁻ sensing.
机构信息
Shanghai Key Laboratory of Functional Materials Chemistry & Department of Chemistry, East China University of Science and Technology, 130 Meilong Road, Shanghai, PR China.
出版信息
Chem Commun (Camb). 2011 Aug 14;47(30):8539-41. doi: 10.1039/c1cc13160e. Epub 2011 Jun 28.
PMID:21709927
Abstract
We demonstrate that the coupling system of negatively capped CdSe/ZnS QDs with an oxidized Cytochrome c (Cyt c) is capable of the fluorescent imaging of a superoxide radical (O(2)˙⁻) with high sensitivity and specificity in living cells, without interference from other Reactive Oxygen Species (ROS) or relevant intracellular components.
摘要
我们证明了带负帽的 CdSe/ZnS QDs 与氧化型细胞色素 c（Cyt c）的偶联体系能够在活细胞中高灵敏度和特异性地荧光成像超氧自由基（O(2)˙⁻），而不会受到其他活性氧（ROS）或相关细胞内成分的干扰。
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