University Surgical Unit, National Hospital of Sri Lanka, Colombo, Sri Lanka.
J Gastrointest Surg. 2011 Sep;15(9):1562-7. doi: 10.1007/s11605-011-1588-5. Epub 2011 Jun 28.
Inflammatory bowel diseases (IBD) include ulcerative colitis (UC) and Crohn's disease (CD), which are chronic inflammatory conditions affecting the gastrointestinal tract. There are only few published data on disease characteristics of IBD related to South Asia.
To provide the disease characteristics of the IBD patients who presented to a tertiary care hospital in South Asia.
Patients with an established diagnosis of IBD were identified after a review of their medical records and demographics, and disease characteristics and indications for surgical treatment were analyzed.
A total of 184 patients (women = 101, 54.9%; UC = 153, 83.2%) were included. Female preponderance was observed for UC (male/female ratio =1:1.5) and male for CD (male/female = 2:1). Mean age at the time of diagnosis was 36.3 (range 7-71) years. CD was diagnosed at a significantly younger age than UC (27.35 ± 10.22 vs. 38.14 ± 13.05 years, p < 0.0001). CD showed a peak age of onset in the third decade and that for UC was in the fourth decade. The mean duration of IBD was 8.17 (range 1-28) years. Presenting complaint of the majority (73.7%) of UC patients was blood and mucous diarrhea and that for CD (77.4%, 24/31) was left-sided abdominal pain. Only 9.5% (n = 18) had at least one extra-intestinal manifestation. Among UC patients, 51.7% (n = 79) had left-sided colitis and panproctocolitis was found in 18.3% (n = 28). In IBD patients, 14.1% (n = 26) underwent surgery. Only one patient developed malignancy.
The majority of UC patients had left-sided colitis. CD compared to UC was diagnosed at a younger age. However, compared to data reported for some Western countries, extra-intestinal manifestations and malignancy rates were lower.
炎症性肠病（IBD）包括溃疡性结肠炎（UC）和克罗恩病（CD），是影响胃肠道的慢性炎症性疾病。目前仅有少量关于南亚地区 IBD 疾病特征的文献报道。
提供在南亚一家三级护理医院就诊的 IBD 患者的疾病特征。
通过回顾病历和人口统计学资料，确定已确诊的 IBD 患者，并分析其疾病特征和手术治疗指征。
共纳入 184 例患者（女性 101 例，54.9%；UC 153 例，83.2%）。UC 以女性为主（男/女比例为 1:1.5），CD 以男性为主（男/女比例为 2:1）。诊断时的平均年龄为 36.3（7-71）岁。CD 的诊断年龄明显小于 UC（27.35 ± 10.22 岁比 38.14 ± 13.05 岁，p<0.0001）。CD 的发病高峰在 30 岁，UC 的发病高峰在 40 岁。IBD 的平均病程为 8.17（1-28）年。大多数 UC 患者（73.7%）的首发症状为血便伴黏液腹泻，而 CD（77.4%，24/31）为左下腹疼痛。仅有 9.5%（n=18）的患者至少有一种肠外表现。在 UC 患者中，51.7%（n=79）为左侧结肠炎，18.3%（n=28）为全结肠炎。IBD 患者中有 14.1%（n=26）接受了手术治疗。仅 1 例患者发生恶性肿瘤。
大多数 UC 患者为左侧结肠炎。与 UC 相比，CD 的诊断年龄更小。然而，与一些西方国家报道的数据相比，肠外表现和恶性肿瘤的发生率较低。
