羧基甜菜碱甲基丙烯酸酯聚合物提供了强大而持久的抗细胞黏附保护。
Carboxybetaine methacrylate polymers offer robust, long-term protection against cell adhesion.
机构信息
Department of Chemical and Biological Engineering, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA.
出版信息
Langmuir. 2011 Sep 6;27(17):10800-4. doi: 10.1021/la201066y. Epub 2011 Aug 16.
Abstract
Films of poly(carboxybetaine methacrylate), poly(CBMA), grafted onto microetched gold slides are effective in preventing nonspecific adhesion of cells of different types. The degree of adhesion resistance is comparable to that achieved with the self-assembled monolayers, SAMs, of oligo(ethylene glycol) alkanethiolates. In sharp contrast to the SAMs, however, substrates protected with poly(CBMA) can be stored in dry state without losing their protective properties for periods up to 2 weeks.
摘要
接枝到微蚀刻金片上的聚（羧酸甜菜碱甲基丙烯酸酯）（poly(CBMA)）薄膜可有效防止不同类型细胞的非特异性黏附。黏附阻力的程度与寡聚（乙二醇）烷硫醇自组装单层（SAMs）相当。然而，与 SAMs 形成鲜明对比的是，用聚（CBMA）保护的基底可以在干燥状态下储存长达 2 周而不会失去其保护性能。
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本文引用的文献
1
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Adv Mater. 2005 Jun 6;17(11):1361-1365. doi: 10.1002/adma.200402086.
2
Zwitterionic SAMs that Resist Nonspecific Adsorption of Protein from Aqueous Buffer.抵抗来自水性缓冲液中蛋白质非特异性吸附的两性离子自组装单分子膜。
Langmuir. 2001 May 1;17(9):2841-2850. doi: 10.1021/la0015258.
3
Cell motility on micropatterned treadmills and tracks.细胞在微图案化跑步机和轨道上的运动。
Soft Matter. 2007 May 23;3(6):672-679. doi: 10.1039/b617308j.
4
Soft Lithography.软光刻
Angew Chem Int Ed Engl. 1998 Mar 16;37(5):550-575. doi: 10.1002/(SICI)1521-3773(19980316)37:5<550::AID-ANIE550>3.0.CO;2-G.
5
Short-term molecular polarization of cells on symmetric and asymmetric micropatterns.细胞在对称和不对称微图案上的短期分子极化
Soft Matter. 2010 Jul 21;6(14):3257-3268. doi: 10.1039/B922647H.
6
Ultralow-fouling, functionalizable, and hydrolyzable zwitterionic materials and their derivatives for biological applications.超低污染、功能化、可水解两性离子材料及其衍生物在生物领域的应用。
Adv Mater. 2010 Mar 5;22(9):920-32. doi: 10.1002/adma.200901407.
7
Dynamic control over cell adhesive properties using molecular-based surface engineering strategies.利用基于分子的表面工程策略对细胞黏附性质进行动态控制。
Chem Soc Rev. 2010 Jan;39(1):354-78. doi: 10.1039/b906608j. Epub 2009 Oct 14.
8
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