Department of Nutrition and Food Hygiene, School of Radiation Medicine and Public Health, Soochow University, Suzhou, China.
Menopause. 2011 Nov;18(11):1256-62. doi: 10.1097/gme.0b013e31821bfa24.
Strong evidence suggests that C-reactive protein (CRP) is a novel risk factor for cardiovascular disease. We aimed to examine the effect of soy isoflavones on circulating CRP concentrations in postmenopausal women by conducting a meta-analysis of randomized controlled trials. We performed a literature search using PubMed, the Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov databases in December 2010 for randomized controlled trials conducted in postmenopausal women, using soy foods with isoflavones or isoflavone extracts as treatment, and with a report of CRP change. A meta-analysis was performed using a fixed-effects model or a random-effects model to calculate the combined effect size. In addition, subgroup and metaregression analyses were carried out to examine the influences of study designs and participant characteristics on the effect estimates. A pooled analysis of 14 trials showed a slight, but not significant, reduction of 0.17 mg/L (95% CI, -0.38 to 0.04; P = 0.12) in CRP concentrations among postmenopausal women with soy isoflavone intervention compared with controls. No substantial heterogeneity was observed. Subgroup analyses showed that soy isoflavones significantly lowered CRP by 0.70 mg/L (95% CI, -1.17 to -0.23; P = 0.003) among women with baseline CRP concentrations greater than 2.2 mg/L. No significant changes in CRP were observed in the other subgroups. Metaregression analysis further revealed that baseline CRP was a potential effect modifier of isoflavone treatment in lowering CRP. The present meta-analysis found insufficient evidence that soy isoflavones significantly reduce CRP concentrations in postmenopausal women. However, soy isoflavones may produce a significant reduction in CRP among postmenopausal women with elevated CRP.
有强有力的证据表明 C 反应蛋白（CRP）是心血管疾病的一个新的危险因素。我们旨在通过对随机对照试验进行荟萃分析来研究大豆异黄酮对绝经后妇女循环 CRP 浓度的影响。我们于 2010 年 12 月使用 PubMed、Cochrane 对照试验中心注册库和 ClinicalTrials.gov 数据库进行了文献检索，检索绝经后妇女中使用含有异黄酮或异黄酮提取物的大豆食品作为治疗方法的随机对照试验，并报告 CRP 变化情况。使用固定效应模型或随机效应模型进行荟萃分析，以计算合并效应大小。此外，还进行了亚组和荟萃回归分析，以检验研究设计和参与者特征对效应估计值的影响。对 14 项试验的汇总分析显示，与对照组相比，大豆异黄酮干预组绝经后妇女 CRP 浓度略有但无统计学意义的降低 0.17mg/L（95%CI，-0.38 至 0.04；P=0.12）。未观察到明显的异质性。亚组分析显示，对于基线 CRP 浓度大于 2.2mg/L 的女性，大豆异黄酮可显著降低 CRP 浓度 0.70mg/L（95%CI，-1.17 至-0.23；P=0.003）。在其他亚组中，CRP 未发生明显变化。荟萃回归分析进一步表明，基线 CRP 是异黄酮治疗降低 CRP 的潜在效应修饰剂。本荟萃分析发现，没有充分证据表明大豆异黄酮可显著降低绝经后妇女的 CRP 浓度。然而，大豆异黄酮可能会使 CRP 升高的绝经后妇女的 CRP 显著降低。
