Cananginones A–I，来自毛果算盘子茎皮的线性乙酰氧基酮。
Cananginones A–I, linear acetogenins from the stem bark of Miliusa velutina [corrected].
机构信息
Natural Products Research Unit, Department of Chemistry, Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
出版信息
Phytochemistry. 2011 Oct;72(14-15):1859-64. doi: 10.1016/j.phytochem.2011.05.013. Epub 2011 Jun 27.
Nine linear C23 and C21 acetogenins, named cananginones A-I (1-9), were isolated from stem bark of Miliusa velutina [corrected] . Their structures were established by spectroscopic methods. These compounds showed cytotoxicity against three cancer cell lines (KB, MCF7 and NCI-H187) with IC₅₀ values in the range 16.6-129.7 μM. Only 5 showed weak antimalarial activity against Plasmodium falciparum. In addition, 8 and 9 exhibited weak antifungal activity against Candida albicans.
从毛瑞榈 [更正] 的茎皮中分离得到了 9 种线性 C23 和 C21 乙酰氧基醇，命名为坎那金酮 A-I（1-9）。通过光谱方法确定了它们的结构。这些化合物对三种癌细胞系（KB、MCF7 和 NCI-H187）表现出细胞毒性，IC₅₀ 值在 16.6-129.7 μM 范围内。只有 5 种对恶性疟原虫表现出较弱的抗疟活性。此外，8 和 9 对白色念珠菌表现出较弱的抗真菌活性。
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