İstanbul Üniversitesi Onkoloji Enstitüsü, Çapa, 34093 İstanbul, Turkey.
Jpn J Clin Oncol. 2011 Aug;41(8):1037-40. doi: 10.1093/jjco/hyr080. Epub 2011 Jun 29.
Adult extrarenal nephroblastomas (Wilms' tumor) are extremely rare tumors. They show a higher incidence of non-seminomatous elements and these so-called 'teratoid' Wilms' tumors are suggested to be of germ cell origin. To date, however, the number of reported cases with gonadal teratoma containing nephroblastoma is very low, and due to this reason, there are no standardized criteria for the categorization and treatment of these lesions. To our knowledge, the first case of nephroblastoma arising in a non-atrophic testis has been reported and it is associated with a teratoma as morphologically identifiable germ cell tumor and rhabdomyosarcoma as a second non-germ cell element. We report the second case of an adult nephroblastoma that arose within the primary testicular teratoma in a non-atrophic testis. Teratoma and nephroblastoma within the same testis may have an important point to clarify the developmental mechanism in nephroblastomatous differentiation of germ cell tumors.
成人肾外肾母细胞瘤（Wilms 瘤）是极为罕见的肿瘤。它们表现出更高的非精原细胞瘤成分发生率，这些所谓的“畸胎瘤样”Wilms 瘤被认为来源于生殖细胞。然而，迄今为止，报道的含有肾母细胞瘤的性腺畸胎瘤病例非常少，由于这个原因，这些病变的分类和治疗没有标准化的标准。据我们所知，首例发生在非萎缩睾丸中的肾母细胞瘤已经被报道，它与畸胎瘤一样是形态上可识别的生殖细胞肿瘤，横纹肌肉瘤是第二个非生殖细胞成分。我们报告了第二例成人肾母细胞瘤，它发生在非萎缩睾丸的原发性睾丸畸胎瘤内。同一睾丸内的畸胎瘤和肾母细胞瘤可能有一个重要的要点，可以阐明生殖细胞肿瘤肾母细胞瘤分化的发育机制。
