Department of Urology, Shiga University of Medical Science, Otsu, Shiga, Japan.
Int J Urol. 2013 May;20(5):544-6. doi: 10.1111/j.1442-2042.2012.03197.x. Epub 2012 Oct 17.
We report a rare case of stage I non-seminomatous testicular germ cell tumor with malignant transformation. The patient received two cycles of chemotherapy (cisplatin, bleomycin and etoposide) tailored to testicular germ cell tumors as an adjuvant therapy after orchiectomy. However, 22 months later, the patient developed a metastasis in the occipital region that consisted of solely rhabdomyosarcoma through malignant transformation of a teratoma component. This case highlights an issue related to adjuvant chemotherapy for testicular germ cell tumors with components of malignant transformation.
我们报告了一例罕见的 I 期非精原细胞瘤性睾丸生殖细胞肿瘤恶变。患者在睾丸切除术之后接受了两个周期的顺铂、博来霉素和依托泊苷化疗(适用于睾丸生殖细胞肿瘤)作为辅助治疗。然而,22 个月后,患者在后头部发生转移,通过畸胎瘤成分的恶变,该转移仅由横纹肌肉瘤组成。这个病例强调了与具有恶变成分的睾丸生殖细胞肿瘤辅助化疗相关的一个问题。