[血清素对胸腺抗原非特异性抑制细胞的作用]
[Effects of serotonin on antigen-nonspecific suppressors of the thymus].
作者信息
Morozova N B
出版信息
Biull Eksp Biol Med. 1990 Jul;110(7):68-70.
Study of nonspecific suppressors of the thymus in inhibition of immune response by serotonin is carried out in CBA mice. We have tested a selective effect of 2-deoxyguanosine on antigen nonspecific T suppressors of the thymus. In syngeneic adoptive transfer on the 3rd day after immunization it is established that antigen nonspecific immune response (rosette-forming cells) after serotonin treatment amounts to 71%, in intact animals--37%. When estimating the plague forming cells the antigen nonspecific suppressive thymocytes make up 21.9% in immune mice, 62.5% in immune mice after serotonin treatment, 29.7% in intact animals.
在CBA小鼠中开展了关于胸腺非特异性抑制因子对血清素抑制免疫反应作用的研究。我们测试了2-脱氧鸟苷对胸腺抗原非特异性T抑制因子的选择性作用。在免疫后第3天进行同基因过继转移实验，结果表明，血清素处理后抗原非特异性免疫反应（形成玫瑰花结细胞）为71%，未处理的动物为37%。在评估噬菌斑形成细胞时，抗原非特异性抑制性胸腺细胞在免疫小鼠中占21.9%，血清素处理后的免疫小鼠中占62.5%，未处理的动物中占29.7%。
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