Devoino L, Idova G, Cheido M, Alperina E, Morozova N
Methods Find Exp Clin Pharmacol. 1986 Mar;8(3):175-81.
The intraimmune pathways and mechanisms of action of the serotoninergic and dopaminergic systems in exerting a modulating effect upon immunogenesis are presented. Experiments were carried out in mice immunized with sheep red blood cells (1 X 10(7); 5 X 10(6)). Participation of the hypothalamic-pituitary complex in the monoaminergic mechanisms of stimulation and inhibition of rosette formation was revealed. Dissection of the pituitary stalk prevented stimulation of rosette formation by apomorphine (1 mg/kg i.p) and bupropion (20 mg/kg) and the reduction of the immune response by haloperidol (1 mg/kg), 5-hydroxytryptophan (300 mg/kg) and serotonin (50 mg/kg). The results of syngeneic cellular transfer of different immunocompetent organs showed that serotonin injection induced an increase in B-suppressor activity of bone marrow cells, reaching maximal value in the inductive period (day 3 of the immune response). B-Lymphocyte suppression in donors not treated with serotonin peaked on day 5 of the immune response. Stimulation of the immune response under activation of the dopaminergic system after apomorphine administration was provided by an increase in T-helper activity in the bone marrow cells, mainly with respect to IgM-response. The suppressive activity of bone marrow T cells on IgM- and IgG-immune responses was increased in nonimmunized donors treated with serotonin or haloperidol. The mechanisms of neurochemical multichannel immunomodulation by means of redistribution of cellular populations resulting in an increase in suppressors or helpers in bone marrow are discussed.
本文介绍了血清素能和多巴胺能系统在免疫发生过程中发挥调节作用的免疫内途径及作用机制。实验用绵羊红细胞（1×10⁷；5×10⁶）对小鼠进行免疫。研究发现下丘脑 - 垂体复合体参与了刺激和抑制玫瑰花结形成的单胺能机制。切断垂体柄可阻止阿扑吗啡（1mg/kg腹腔注射）和安非他酮（20mg/kg）对玫瑰花结形成的刺激，以及氟哌啶醇（1mg/kg）、5 - 羟色氨酸（300mg/kg）和血清素（50mg/kg）对免疫反应的降低作用。不同免疫活性器官的同基因细胞转移结果表明，注射血清素可诱导骨髓细胞B抑制活性增加，在诱导期（免疫反应第3天）达到最大值。未用血清素处理的供体中B淋巴细胞抑制在免疫反应第5天达到峰值。阿扑吗啡给药后多巴胺能系统激活时免疫反应的刺激是由骨髓细胞中T辅助活性增加介导的，主要针对IgM反应。在用血清素或氟哌啶醇处理的未免疫供体中，骨髓T细胞对IgM和IgG免疫反应的抑制活性增加。本文还讨论了通过细胞群体重新分布实现神经化学多通道免疫调节的机制，这种重新分布导致骨髓中抑制细胞或辅助细胞增加。
