Eliseeva L S
Fiziol Zh SSSR Im I M Sechenova. 1987 Aug;73(8):1084-9.
Low dosages of serotonin and 5-hydroxytryptophan were found to stimulate rosette-forming process in spleens of male CBA mice (5 X 10(6)) immunized with sheep red blood cells, in contrast to high dosages that are known to induce inhibition. The above finding suggests a bimodality of serotoninergic immunomodulation. Immune responses were compared between shamoperated, adrenalectomized, thymectomized mice and mice with lesion of hypothalamo-pituitary complex (the destruction of pituitary or its stalk). It was shown, that neither hypothalamo-pituitary-adrenal system by means of which the inhibitory effect of serotonin (high dose) was released, no thymus, where the increase of rosette-forming process was released in adrenalectomized mice which obtained high doses of serotonin. The dosage-response curve suggests mediating of opposite serotonin effects via serotonin reactive structures with different serotonin sensitivity.
研究发现，低剂量的血清素和5-羟色氨酸能刺激用绵羊红细胞免疫的雄性CBA小鼠（5×10⁶）脾脏中的玫瑰花结形成过程，这与已知会诱导抑制作用的高剂量情况相反。上述发现表明血清素能免疫调节具有双相性。对假手术、肾上腺切除、胸腺切除的小鼠以及下丘脑 - 垂体复合体有损伤（垂体或其柄部被破坏）的小鼠的免疫反应进行了比较。结果表明，血清素（高剂量）通过其释放抑制作用的下丘脑 - 垂体 - 肾上腺系统，以及在接受高剂量血清素的肾上腺切除小鼠中玫瑰花结形成过程增加所涉及的胸腺，均未起到作用。剂量 - 反应曲线表明，血清素的相反作用是通过对血清素敏感性不同的血清素反应结构介导的。
