Stratul Stefan-Ioan, Sculean Anton, Rusu Darian, Didilescu Andreea, Kasaj Adrian, Jentsch Holger
Department of Periodontology, Faculty of Dental Medicine, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
Quintessence Int. 2011 Jul-Aug;42(7):555-63.
The aim of the study was to evaluate the impact of smoking on a prolongated chlorhexidine digluconate regimen after scaling and root planing. Forty-two smokers (test group) and 85 nonsmoking patients (control group) with generalized chronic periodontitis were examined for clinical attachment level (CAL), probing depth (PD), bleeding on probing (BoP), and Plaque Index (Pl) at baseline and after 1 and 3 months. During scaling and root planing, a 0.2% chlorhexidine digluconate solution and a 1% chlorhexidine digluconate gel were used. The subjects used a 0.2% chlorhexidine digluconate solution twice daily for 3 months. The Mann-Whitney U and Wilcoxon tests were used for statistical analysis. There were significant improvements of all studied variables after 1 and 3 months in both groups. After 3 months, the mean improvement in the test group was 1.62 mm for CAL, 2.85 mm for PD, and 48% for BoP; in the control group, the values were 2.18 mm for CAL, 2.81 mm for PD, and 47% for BoP. Only the maximum changes of CAL between 1 and 3 months (test group, 0.32 mm vs 0.69 mm in the control group) and PD (test group, 0.47 mm vs 0.76 mm in the control group) were significantly different between the groups (P < .05 and P = .05, respectively). The present data appear to suggest that the use of chlorhexidine digluconate twice daily during a period of 3 months following nonsurgical periodontal therapy may result in significant clinical improvements in smokers and nonsmokers.
本研究的目的是评估吸烟对龈下刮治及根面平整术后延长使用葡萄糖酸洗必泰方案的影响。对42名患有广泛性慢性牙周炎的吸烟者（试验组）和85名非吸烟患者（对照组）在基线、1个月和3个月后检查临床附着水平（CAL）、探诊深度（PD）、探诊出血（BoP）和菌斑指数（Pl）。在龈下刮治及根面平整过程中，使用了0.2%葡萄糖酸洗必泰溶液和1%葡萄糖酸洗必泰凝胶。受试者每天使用0.2%葡萄糖酸洗必泰溶液两次，持续3个月。采用Mann-Whitney U检验和Wilcoxon检验进行统计分析。两组在1个月和3个月后，所有研究变量均有显著改善。3个月后，试验组CAL的平均改善为1.62mm，PD为2.85mm，BoP为48%；对照组中CAL值为2.18mm，PD为2.81mm，BoP为47%。两组之间仅1至3个月期间CAL的最大变化（试验组0.32mm，对照组0.69mm）和PD（试验组0.47mm，对照组0.76mm）存在显著差异（分别为P < 0.05和P = 0.05）。目前的数据似乎表明，在非手术牙周治疗后的3个月内每天使用两次葡萄糖酸洗必泰可能会使吸烟者和非吸烟者在临床上得到显著改善。
