Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Immunol Res. 2011 Aug;50(2-3):113-7. doi: 10.1007/s12026-011-8216-z.
NF-κB family transcription factors are a common downstream target for inducible transcription mediated by many different cell-surface receptors, especially those receptors involved in inflammation and adaptive immunity. It is now clear that different classes of receptors employ different proximal signaling strategies to activate the common NF-κB signaling components, such as the IKK complex. For antigen receptors expressed by T and B cells, this pathway requires a complex of proteins including the proteins Carma1, Bcl10, and Malt1. Here, we discuss some of what is known about regulation of these proteins downstream of TCR/CD3 and co-stimulatory CD28 signaling. We also discuss another unique aspect of TCR-mediated NF-κB activation, i.e., the spatial restriction imposed on signaling events by the formation of the immunological synapse between a T cell and antigen-presenting cell presenting specific peptide/MHC.
NF-κB 家族转录因子是许多不同细胞表面受体介导的诱导性转录的常见下游靶标，尤其是那些参与炎症和适应性免疫的受体。现在很清楚，不同类别的受体采用不同的近端信号策略来激活常见的 NF-κB 信号成分，如 IKK 复合物。对于 T 细胞和 B 细胞表达的抗原受体，该途径需要包括 Carma1、Bcl10 和 Malt1 在内的蛋白质复合物。在这里，我们讨论了 TCR/CD3 和共刺激 CD28 信号下游这些蛋白质调节的一些已知内容。我们还讨论了 TCR 介导的 NF-κB 激活的另一个独特方面，即 TCR 与呈递特定肽/MHC 的抗原呈递细胞之间形成免疫突触对信号事件施加的空间限制。
