Environmental Health Sciences, Department of Public Health, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA 01003, USA.
Arch Toxicol. 2011 Dec;85(12):1495-8. doi: 10.1007/s00204-011-0728-8. Epub 2011 Jun 30.
In his Nobel Prize Lecture of December 12, 1946, Hermann J. Muller argued that the dose-response for radiation-induced germ cell mutations was linear and that there was "no escape from the conclusion that there is no threshold". However, assessment of correspondence between Muller and Curt Stern 1 month prior to his Nobel Prize Lecture reveals that Muller knew the results and implications of a recently completed study at the University of Rochester under the direction of Stern, which directly contradicted his Nobel Prize Lecture. This finding is of historical importance since Muller's Nobel Lecture gained considerable international attention and is a turning point in the acceptance of the linearity model in risk assessment for germ cell mutations and carcinogens.
在 1946 年 12 月 12 日的诺贝尔奖演讲中，赫尔曼·J·穆勒（Hermann J. Muller）认为，辐射诱导的生殖细胞突变的剂量反应呈线性，并且“无法得出没有阈值的结论”。然而，对穆勒在获得诺贝尔奖演讲前一个月与 Curt Stern 的评估结果进行评估后发现，穆勒知道斯特恩（Stern）在罗切斯特大学（University of Rochester）完成的一项最新研究的结果和意义，该研究直接与他的诺贝尔奖演讲相矛盾。这一发现具有历史意义，因为穆勒的诺贝尔奖演讲引起了国际社会的广泛关注，并且是接受生殖细胞突变和致癌物风险评估中线性模型的转折点。
