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美国国家科学院如何误导世界社会对癌症风险评估:新发现挑战线性剂量反应的历史基础。

How the US National Academy of Sciences misled the world community on cancer risk assessment: new findings challenge historical foundations of the linear dose response.

机构信息

Department of Public Health, Environmental Health Sciences, University of Massachusetts, Morrill I, N344, Amherst, MA, 01003, USA,

出版信息

Arch Toxicol. 2013 Dec;87(12):2063-81. doi: 10.1007/s00204-013-1105-6. Epub 2013 Aug 4.

Abstract

This paper extends several recent publications indicating that Hermann J. Muller: (1) Made deceptive statements during his Noble Prize Lecture on December 12, 1946, that were intended to promote the acceptance of the linear dose-response model for risk assessment for ionizing radiation and (2) that such actions of Muller were masked by a series of decisions by Muller's long-time colleague and esteemed radiation geneticist Curt Stern, affecting key publications in the mutation literature. Such actions further enhanced acceptance of the linearity dose-response model while preventing Muller's deceptions from being discovered. This paper provides documentation that Muller reinforced such practices within the scientific literature in the early 1950s, by supporting scientifically questionable actions of Stern. Detailed documentation is provided that demonstrates how these actions affected national and international risk assessment policy for ionizing radiation and chemical carcinogens via the recommendations of the National Academy of Sciences Biological Effects of Atomic Radiation committee in 1956, to adopt the linear dose-response model.

摘要

本文扩展了最近的几项研究成果,这些成果表明赫尔曼·J·穆勒(Hermann J. Muller):(1)在 1946 年 12 月 12 日的诺贝尔演讲中发表了欺骗性声明,旨在促进接受线性剂量反应模型来评估电离辐射风险;(2)穆勒的这些行为被他的长期同事、备受尊敬的辐射遗传学家库尔特·斯特恩(Curt Stern)的一系列决定所掩盖,这些决定影响了突变文献中的关键出版物。这些行为进一步增强了对线性剂量反应模型的接受程度,同时防止了穆勒的欺骗行为被发现。本文提供了证据,证明穆勒在 20 世纪 50 年代通过支持斯特恩的科学上有疑问的行为,在科学文献中加强了这种做法。详细的文件证明了这些行为如何通过 1956 年美国国家科学院原子辐射生物效应委员会的建议,影响了电离辐射和化学致癌物的国家和国际风险评估政策,以采用线性剂量反应模型。

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