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新发现的信件:为何 Muller 未能引用 Snell 的阴性小鼠突变发现,从而保留了自己获得诺贝尔奖的机会。

Newly discovered letter: why Muller failed to cite the negative mouse mutation findings of Snell, preserving his chances to receive the Nobel Prize.

机构信息

Department of Environmental Health Sciences, Morrill I, N344, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA, 01003, USA.

Retired from Oak Ridge National Laboratory, TN; 4088 Nottinghill Gate Road, Upper Arlington, OH, 43220, USA.

出版信息

Arch Toxicol. 2024 Aug;98(8):2739-2741. doi: 10.1007/s00204-024-03807-1. Epub 2024 Jun 22.

Abstract

A recently acquired letter between Hermann Muller and his wife (March 21, 1933) reveals that Muller had learned that he had been nominated for the Nobel Prize in 1932 with about 1/3 of the total votes being supportive. Muller was hopeful that over time sufficient votes would lead to receiving the award. The knowledge of Muller on this matter and its timing provide a likely explanation why Muller never cited the negative mouse mutation findings of George Snell, performed under Muller's direction during that time period. This action of Muller, along with the failure of Snell to promote his discovery, greatly reduced the chances that those findings would complicate his attempt to garner support for his LNT single-hit model and its application to hereditary and cancer risk assessment. It also helped Muller achieve the Nobel Prize, allowing him the necessary international visibility to promote his ideologically driven ionizing radiation-related LNT-based paradigm.

摘要

最近发现的一封赫尔曼·穆勒(Hermann Muller)及其妻子之间的信件(1933 年 3 月 21 日)显示,穆勒已经得知他在 1932 年获得了诺贝尔生理学或医学奖提名,其中约有三分之一的选票表示支持。穆勒希望随着时间的推移,有足够的选票能够让他获得该奖项。穆勒对这件事的了解及其时间点,可能解释了为什么穆勒从未引用过当时在他的指导下进行的乔治·斯内尔(George Snell)的负面老鼠基因突变研究结果。穆勒的这一行为,加上斯内尔未能推广他的发现,大大降低了这些发现会影响他支持他的 LNT 单击模型及其在遗传和癌症风险评估中的应用的可能性。这也帮助穆勒获得了诺贝尔奖,使他获得了必要的国际知名度,以推广他基于意识形态的与电离辐射相关的 LNT 范式。

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