肾上腺素自氧化的动力学研究。
Kinetic investigations of the autoxidation of adrenalin.
作者信息
Bors W, Michel C, Saran M, Lengfelder E
出版信息
Z Naturforsch C Biosci. 1978 Nov-Dec;33(11-12):891-6. doi: 10.1515/znc-1978-11-1215.
Generation rates of superoxide anions (O2-) by autoxidizing adrenalin at pH 9.5 were determined in solutions containing either superoxide dismutase (0.85 M-1 S-1) or hydroxylamine (0.0185 M-1 S-1) as competitive scavengers. The rate constants of O2- with adrenalin and hydroxylamine were calculated for neutral and alkaline solutions. The respective values were for adrenalin: 5.6 X 10(4) M-1 S-1, pH 7.8; 7.0 X 10(3) M-1 S-1, pH 9.5--and for hydroxylamine 5.9 X 10(4) M-1 S-1, pH 7.8; 3.4 X 10(4) M-1 S-1, pH 9.5. The effects of various competitors and O2- sources on the rate constants were compared.
在含有超氧化物歧化酶（0.85 M⁻¹ S⁻¹）或羟胺（0.0185 M⁻¹ S⁻¹）作为竞争性清除剂的溶液中，测定了在pH 9.5条件下自氧化肾上腺素产生超氧阴离子（O₂⁻）的速率。计算了中性和碱性溶液中O₂⁻与肾上腺素和羟胺的反应速率常数。肾上腺素的相应值为：pH 7.8时为5.6×10⁴ M⁻¹ S⁻¹；pH 9.5时为7.0×10³ M⁻¹ S⁻¹。羟胺的相应值为：pH 7.8时为5.9×10⁴ M⁻¹ S⁻¹；pH 9.5时为3.4×10⁴ M⁻¹ S⁻¹。比较了各种竞争剂和O₂⁻来源对反应速率常数的影响。
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