巴基斯坦部分药用植物的抗菌活性。

Antibacterial activity of some selected medicinal plants of Pakistan.

机构信息

Department of Microbiology, Quaid-i-Azam University, Islamabad, Pakistan.

出版信息

BMC Complement Altern Med. 2011 Jun 30;11:52. doi: 10.1186/1472-6882-11-52.

DOI:10.1186/1472-6882-11-52

PMID:21718504

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3141602/

Abstract

BACKGROUND

Screening of the ethnobotenical plants is a pre-requisite to evaluate their therapeutic potential and it can lead to the isolation of new bioactive compounds.

METHODS

The crude extracts and fractions of six medicinal important plants (Arisaema flavum, Debregeasia salicifolia, Carissa opaca, Pistacia integerrima, Aesculus indica, and Toona ciliata) were tested against three Gram positive and two Gram negative ATCC bacterial species using the agar well diffusion method.

RESULTS

The crude extract of P. integerrima and A. indica were active against all tested bacterial strains (12-23 mm zone of inhibition). Other four plant's crude extracts (Arisaema flavum, Debregeasia salicifolia, Carissa opaca, and Toona ciliata) were active against different bacterial strains. The crude extracts showed varying level of bactericidal activity. The aqueous fractions of A. indica and P. integerrima crude extract showed maximum activity (19.66 and 16 mm, respectively) against B. subtilis, while the chloroform fractions of T. ciliata and D. salicifolia presented good antibacterial activities (13-17 mm zone of inhibition) against all the bacterial cultures tested.

CONCLUSION

The methanol fraction of Pistacia integerrima, chloroform fractions of Debregeasia salicifolia &Toona ciliata and aqueous fraction of Aesculus indica are suitable candidates for the development of novel antibacterial compounds.

摘要

背景

筛选民族植物学植物是评估其治疗潜力的前提，它可以导致新的生物活性化合物的分离。

方法

采用琼脂孔扩散法，对 6 种药用重要植物（Arisaema flavum、Debregeasia salicifolia、Carissa opaca、Pistacia integerrima、Aesculus indica 和 Toona ciliata）的粗提取物和馏分进行了三种革兰氏阳性和两种革兰氏阴性 ATCC 细菌的测试。

结果

P. integerrima 和 A. indica 的粗提取物对所有测试的细菌株（12-23 毫米的抑制带）均有活性。其他四种植物的粗提取物（Arisaema flavum、Debregeasia salicifolia、Carissa opaca 和 Toona ciliata）对不同的细菌株有活性。粗提取物表现出不同程度的杀菌活性。A. indica 和 P. integerrima 粗提取物的水相部分对枯草芽孢杆菌表现出最大的活性（分别为 19.66 和 16 毫米），而 T. ciliata 和 D. salicifolia 的氯仿部分对所有测试的细菌培养物均表现出良好的抗菌活性（13-17 毫米的抑制带）。