Czernichow Sébastien, Thomas Daniel, Bruckert Eric
Unité de recherche d'épidémiologie nutritionnelle, UMR Inserm U557, INRA, CNAM, UP13, CRNH-Idf, Faculté SMBH, 74, rue Marcel Cachin, 93017 Bobigny, France.
Med Sci (Paris). 2011 Jun-Jul;27(6-7):614-8. doi: 10.1051/medsci/2011276013. Epub 2011 Jul 1.
Omega-6 polyunsaturated fatty acids (n-6 PUFA) are well known for their critical role in many physiological functions and reduce risks of cardiovascular disease (CVD). However, some argue that excessive consumption of n-6 PUFA may lead to adverse effects on health and therefore recommend reducing dietary n-6 PUFA intake or fixing an upper limit. Epidemiological studies show that n-6 PUFA dietary intake significantly lowers blood LDL-cholesterol levels. In addition, n-6 PUFA intake lower several cardiovascular risk factors such as blood pressure, inflammatory markers, haemostatic parameters and obesity. Data from prospective cohort and interventional studies converge towards a specific protective role of dietary n-6 PUFA intake, in particular linoleic acid, against CVD. In regards to studies examined in this narrative review, recommendation for n-6 PUFA intake above 5%, and ideally about 10% of total energy appears justified for the prevention of ischemic heart disease.
欧米伽-6多不饱和脂肪酸（n-6 PUFA）因其在多种生理功能中发挥的关键作用以及降低心血管疾病（CVD）风险而广为人知。然而，一些人认为过量摄入n-6 PUFA可能会对健康产生不利影响，因此建议减少膳食中n-6 PUFA的摄入量或设定上限。流行病学研究表明，膳食中摄入n-6 PUFA可显著降低血液中低密度脂蛋白胆固醇水平。此外，摄入n-6 PUFA可降低多种心血管危险因素，如血压、炎症标志物、止血参数和肥胖。前瞻性队列研究和干预性研究的数据均表明，膳食中摄入n-6 PUFA，尤其是亚油酸，对心血管疾病具有特定的保护作用。就本叙述性综述中所研究的各项研究而言，为预防缺血性心脏病，建议n-6 PUFA的摄入量占总能量的5%以上，理想情况下约为10%。
