Nutritional Epidemiology Research Unit, UMR INSERM U557, INRA U1125, CNAM, UP13, CRNH-IdF, Faculté SMBH, 74 rue Marcel Cachin, 93017 Bobigny, France.
Br J Nutr. 2010 Sep;104(6):788-96. doi: 10.1017/S0007114510002096. Epub 2010 Jun 4.
n-6 PUFA are well known for their critical role in many physiological functions and seem to reduce risks of CHD. However, some argue that excessive consumption of n-6 PUFA may lead to adverse effects on health and therefore recommend reducing dietary n-6 PUFA intake or fixing an upper limit. In this context, the present work aimed to review evidence on the link between n-6 PUFA and risks of CVD. Epidemiological studies show that n-6 PUFA dietary intake significantly lowers blood LDL-cholesterol levels. In addition, n-6 PUFA intake does not increase several CVD risk factors such as blood pressure, inflammatory markers, haemostatic parameters and obesity. Data from prospective cohort and interventional studies converge towards a specific protective role of dietary n-6 PUFA intake, in particular linoleic acid, against CVD. n-6 PUFA benefits are even increased when SFA intake is also reduced. In regards to studies examined in this narrative review, recommendation for n-6 PUFA intake above 5 %, and ideally about 10 %, of total energy appears justified.
n-6PUFA 因其在许多生理功能中的关键作用而广为人知，似乎可以降低 CHD 的风险。然而，一些人认为过量摄入 n-6PUFA 可能对健康产生不良影响，因此建议减少饮食中 n-6PUFA 的摄入量或设定上限。在这种情况下，本研究旨在综述 n-6PUFA 与 CVD 风险之间的关联证据。流行病学研究表明，n-6PUFA 的饮食摄入量显著降低了血液 LDL-胆固醇水平。此外，n-6PUFA 的摄入不会增加血压、炎症标志物、止血参数和肥胖等多种 CVD 风险因素。来自前瞻性队列研究和干预研究的数据表明，饮食 n-6PUFA 摄入，特别是亚油酸，对 CVD 具有特定的保护作用。当 SFA 摄入量也减少时，n-6PUFA 的益处甚至会增加。就本叙述性综述中检查的研究而言，建议 n-6PUFA 的摄入量占总能量的 5%以上，理想情况下占 10%左右。
