Department of Oral Surgery and Implant Dentistry, School of Dentistry, University of Granada, Spain.
J Am Dent Assoc. 2011 Jul;142(7):817-24. doi: 10.14219/jada.archive.2011.0270.
Oral melanoacanthoma (OMA) is an uncommon, reactive, pigmented mucocutaneous lesion. It is a rapidly growing, well-circumscribed, small, brown-to-black, solitary or multifocal macule that is characterized histopathologically by proliferation of keratinocytes and pigment-laden dendritic melanocytes.
At the end of a one-month healing period after dental implant surgery, a 63-year-old white woman had pigmented lesions at different oral mucosal sites (hard palate, buccal mucosa and left maxillary tuberosity) that showed macrophages exhibiting iron and melanin in multiple areas of the lamina propria. The authors obtained biopsy specimens from all the lesions for histologic and immunohistochemical analyses and light-microscopy study.
Surgery could have been causal or incidental to the appearance of these lesions. Clinicians should be aware of this possible event and make a correct and pathologically confirmed differential diagnosis.
口腔黑素棘皮瘤（OMA）是一种罕见的、反应性的、色素性的黏膜皮肤病变。它是一种快速生长的、边界清楚的、小的、棕黑色到黑色的、单发或多发的斑疹，组织病理学上的特征是角质形成细胞和含色素的树枝状黑素细胞增生。
在牙种植术后一个月的愈合期结束时，一位 63 岁的白人女性在不同的口腔黏膜部位（硬腭、颊黏膜和左上颌结节）出现色素性病变，固有层的多个部位可见含有铁和黑色素的巨噬细胞。作者从所有病变部位获取活检标本进行组织学和免疫组织化学分析及光镜研究。
手术可能是这些病变出现的原因或偶发事件。临床医生应该意识到这种可能的情况，并做出正确的、经病理证实的鉴别诊断。
