多药外排泵在大肠杆菌K-12生物膜形成中的作用

Roles of multidrug efflux pumps on the biofilm formation of Escherichia coli K-12.

作者信息

Matsumura Kayo, Furukawa Soichi, Ogihara Hirokazu, Morinaga Yasushi

机构信息

Department of Food Bioscience and Biotechnology, College of Bioresource Science, Nihon University, Kameino, Fujisawa, Japan.

出版信息

Biocontrol Sci. 2011 Jun;16(2):69-72. doi: 10.4265/bio.16.69.

DOI:10.4265/bio.16.69

PMID:21719992

Abstract

We genetically analyzed the roles of multidrug efflux pumps on the biofilm formation of Escherichia coli K-12 BW25113. We used 22 mutants missing various genes related to the multidrug efflux pumps and found that the biofilm formation of emrD, emrE, emrK, acrD, acre and mdtE-deleted mutants was extremely decreased. These results indicate that some multidrug efflux pumps significantly contribute to the biofilm formation of E. coli.

摘要

我们对多药外排泵在大肠杆菌K-12 BW25113生物膜形成中的作用进行了基因分析。我们使用了22个缺失与多药外排泵相关的各种基因的突变体，发现缺失emrD、emrE、emrK、acrD、acre和mdtE的突变体的生物膜形成显著减少。这些结果表明，一些多药外排泵对大肠杆菌的生物膜形成有显著贡献。