Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Bandar Tun Razak, Cheras, Kuala Lumpur 56000, Malaysia.
Gastroenterology and Hepatology Unit, Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Bandar Tun Razak, Cheras, Kuala Lumpur 56000, Malaysia.
Nutrients. 2023 Apr 19;15(8):1954. doi: 10.3390/nu15081954.
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent form of chronic liver disease. Fucoxanthin, a red-orange marine carotenoid, is found in natural marine seaweeds with high antioxidant activity and several other remarkable biological features. The aim of this review is to gather evidence of the positive benefits of fucoxanthin on NAFLD. Fucoxanthin provides an extensive list of physiological and biological properties, such as hepatoprotective, anti-obesity, anti-tumor, and anti-diabetes properties, in addition to antioxidant and anti-inflammatory properties. This review focuses on published research on the preventative effects of fucoxanthin on NAFLD from the perspective of human clinical trials, animal experiments , and cell investigations. Using a variety of experimental designs, including treatment dosage, experiment model, and experimental periods, the positive effects of fucoxanthin were demonstrated. Fucoxanthin's biological activities were outlined, with an emphasis on its therapeutic efficacy in NAFLD. Fucoxanthin showed beneficial effects in modulating lipid metabolism, lipogenesis, fatty acid oxidation, adipogenesis, and oxidative stress on NAFLD. A deeper comprehension of NAFLD pathogenesis is essential for the development of novel and effective therapeutic strategies.
非酒精性脂肪性肝病（NAFLD）是最常见的慢性肝病。岩藻黄质是一种红橙色的海洋类胡萝卜素，存在于具有高抗氧化活性和其他几种显著生物学特性的天然海洋海藻中。本综述的目的是收集岩藻黄质对 NAFLD 的有益影响的证据。岩藻黄质具有广泛的生理和生物学特性，如肝保护、抗肥胖、抗肿瘤和抗糖尿病特性，以及抗氧化和抗炎特性。本综述重点关注从人体临床试验、动物实验和细胞研究的角度发表的关于岩藻黄质预防 NAFLD 的研究。使用多种实验设计，包括治疗剂量、实验模型和实验周期，证明了岩藻黄质的积极作用。概述了岩藻黄质的生物学活性，重点介绍了其在 NAFLD 中的治疗功效。岩藻黄质在调节 NAFLD 中的脂质代谢、脂肪生成、脂肪酸氧化、脂肪生成和氧化应激方面显示出有益的效果。深入了解 NAFLD 的发病机制对于开发新的有效治疗策略至关重要。
