Phadia AB, Uppsala University, Uppsala, Sweden.
Int Arch Allergy Immunol. 2011;156(3):282-90. doi: 10.1159/000323891. Epub 2011 Jun 29.
Peanut may cause severe reactions in allergic individuals. The objective was to evaluate IgE antibodies to various recombinant (r) peanut and birch pollen allergens in relation to IgE levels to whole peanut extract and severe allergic reactions to peanut.
Seventy-four Swedish peanut-allergic patients (age: 14-61 years) reported previous peanut exposure and associated symptoms using a questionnaire. Their IgE reactivity to peanut, birch pollen and individual allergen components was analyzed using ImmunoCAP.
Of the 48 subjects sensitized to Ara h 1, 2 or 3, 60% had peanut-specific IgE levels >15 kU(A)/l, while 100% of the subjects without detectable IgE to these allergens had low peanut-specific IgE levels (<10 kU(A)/l). The levels of IgE to rAra h 8, rBet v 1 and birch pollen were highly correlated (r(S) = 0.94, p < 0.0001). Fifty-eight patients reported adverse reactions after accidental or deliberate peanut exposure (oral, inhalation or skin) of whom 41 had IgE to rAra h 1, 2 or 3. Symptoms of respiratory distress were associated with sensitization to Ara h 1, 2 or 3 (56 vs. 18%, p < 0.01). Two cases of anaphylaxis were reported among the individuals sensitized to Ara h 1-3. IgE to rAra h 8, rAra h 9, profilin or cross-reactive carbohydrate determinants were not associated with severe symptoms.
The results indicate that IgE reactivity to Ara h 1, 2 and 3 is associated with severe reactions after exposure to peanut in Swedish patients.
花生可能会引起过敏个体的严重反应。目的是评估与整颗花生提取物和花生严重过敏反应相关的各种重组（r）花生和桦树花粉过敏原的 IgE 抗体与 IgE 水平。
74 名瑞典花生过敏患者（年龄：14-61 岁）使用问卷报告了以前的花生暴露和相关症状。使用 ImmunoCAP 分析了他们对花生、桦树花粉和个别过敏原成分的 IgE 反应性。
在 48 名对 Ara h 1、2 或 3 敏感的受试者中，60%的人有花生特异性 IgE 水平>15 kU(A)/l，而 100%对这些过敏原无检测到 IgE 的人有低花生特异性 IgE 水平(<10 kU(A)/l)。rAra h 8、rBet v 1 和桦树花粉的 IgE 水平高度相关（r(S) = 0.94，p < 0.0001）。58 名患者报告了意外或故意花生暴露（口服、吸入或皮肤）后的不良反应，其中 41 名患者对 rAra h 1、2 或 3 有 IgE。呼吸窘迫症状与对 Ara h 1、2 或 3 的敏感有关（56%比 18%，p < 0.01）。在对 Ara h 1-3 敏感的个体中报告了两例过敏反应。rAra h 8、rAra h 9、丝氨酸蛋白酶抑制剂或交叉反应性碳水化合物决定簇的 IgE 与严重症状无关。
结果表明，在瑞典患者中，对 Ara h 1、2 和 3 的 IgE 反应性与暴露于花生后发生严重反应有关。
