Hancock J T, Henderson L M, Jones O T
Department of Biochemistry, School of Medical Sciences, University of Bristol.
Immunology. 1990 Oct;71(2):213-7.
The generation of superoxide by Epstein-Barr virus (EBV)-transformed human B lymphocytes can be stimulated by a range of compounds; receptor-dependent stimuli include tumour necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta) and lipopolysaccharides (LPS), and independent stimuli include AlF3, A21387 and ionomycin. The stimuli suggest that the activation pathway for the lymphocyte oxidase is similar to that proposed for the neutrophil oxidase. Although the rate of superoxide production was lower than that by neutrophils, the respiratory burst was much prolonged. It is possible that this superoxide generation by lymphocytes may have a biological function.
爱泼斯坦-巴尔病毒（EBV）转化的人B淋巴细胞产生超氧化物可被一系列化合物刺激；受体依赖性刺激物包括肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）和脂多糖（LPS），非依赖性刺激物包括AlF3、A21387和离子霉素。这些刺激表明淋巴细胞氧化酶的激活途径与中性粒细胞氧化酶的激活途径相似。尽管超氧化物的产生速率低于中性粒细胞，但呼吸爆发持续时间长得多。淋巴细胞产生的这种超氧化物可能具有生物学功能。
