Division of Immune Regulation, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
Viral Immunol. 2011 Aug;24(4):351-5. doi: 10.1089/vim.2010.0140. Epub 2011 Jul 1.
Cytomegalovirus (CMV) infection promotes a broad T-cell response, with the resulting memory cells displaying diverse phenotypes. CMV establishes lifelong persistence/latency, and it is thought that viral antigens expressed during this period may regulate the expansion and/or maintenance of "inflationary" CD8 T-memory populations that display an effector memory phenotype. We show here that mouse CMV (MCMV)-specific inflationary memory T cells do not decrease in number after thymectomy, indicating that recent thymic emigrants are not strictly required for their maintenance. Furthermore, persistent MCMV replication in the salivary gland does not significantly impact the T-cell memory compartment, as surgical removal did not alter its composition. These results shed light upon the mechanisms required for maintenance of the large, MCMV-specific T-cell memory pool.
巨细胞病毒 (CMV) 感染可促进广泛的 T 细胞反应，由此产生的记忆细胞表现出不同的表型。CMV 建立终身持续性/潜伏性，据认为在此期间表达的病毒抗原可能调节“膨胀”的 CD8 T 记忆细胞群体的扩增和/或维持，这些细胞群体表现出效应记忆表型。我们在这里表明，鼠巨细胞病毒 (MCMV)-特异性膨胀性记忆 T 细胞在胸腺切除后数量不会减少，这表明近期胸腺迁出细胞并非其维持所必需的。此外，唾液腺中持续的 MCMV 复制对 T 细胞记忆区室没有显著影响，因为手术切除并没有改变其组成。这些结果揭示了维持大量 MCMV 特异性 T 细胞记忆库所需的机制。
