PG Neuroplasticity, Leibniz-Institute for Neurobiology, Magdeburg, Germany.
J Neurochem. 2011 Sep;118(5):695-713. doi: 10.1111/j.1471-4159.2011.07372.x. Epub 2011 Jul 21.
In recent years, substantial progress has been made towards an understanding of the physiological function of EF-hand calcium sensor proteins of the Calmodulin (CaM) superfamily in neurons. This deeper appreciation is based on the identification of novel target interactions, structural studies and the discovery of novel signalling mechanisms in protein trafficking and synaptic plasticity, in which CaM-like sensor proteins appear to play a role. However, not all interactions are of plausible physiological relevance and in many cases it is not yet clear how the CaM signaling network relates to the proposed function of other EF-hand sensors. In this review, we will summarize these findings and address some of the open questions on the functional role of EF-hand calcium binding proteins in neurons.
近年来，人们在理解钙调蛋白（CaM）超家族 EF 手钙离子传感器蛋白在神经元中的生理功能方面取得了实质性进展。这种更深入的认识是基于对新的靶标相互作用、结构研究以及在蛋白质运输和突触可塑性中发现新的信号机制的基础上得出的，在这些过程中，CaM 样传感器蛋白似乎发挥了作用。然而，并非所有的相互作用都具有合理的生理相关性，在许多情况下，尚不清楚 CaM 信号网络与其他 EF 手传感器的拟议功能有何关联。在这篇综述中，我们将总结这些发现，并讨论 EF 手钙离子结合蛋白在神经元中的功能作用方面的一些悬而未决的问题。
