Nutrition and Dietetics Service, Fondazione IRCCS Policlinico San Matteo, Viale Golgi 19, 27100 Pavia, Italy.
Clin Nutr. 2011 Dec;30(6):793-8. doi: 10.1016/j.clnu.2011.04.006. Epub 2011 Jul 1.
BACKGROUND & AIMS: Several tools are available for nutritional screening. We evaluated the risk of mortality associated with the Geriatric Nutritional Risk Index (GNRI) and the Mini Nutritional Assessment (MNA) in newly institutionalised elderly.
A prospective observational study involving 358 elderly newly admitted to a long-term care setting. Hazard ratios (HR) for mortality among GNRI categories and MNA classes were estimated by multivariable Cox's model.
At baseline, 32.4% and 37.4% of the patients were classified as being malnourished (MNA <17) and at severe nutritional risk (GNRI <92), respectively, whereas 57.5% and 35.2%, respectively, were classified as being at risk for malnutrition (MNA 17-23.5) and having low nutritional risk (GNRI 92-98). During a median follow-up of 6.5 years [25th-75th percentile, 5.9-8.6], 297 elderly died. Risk for all-cause mortality was significantly associated with nutritional risk by the GNRI tool (GNRI<92 HR = 1.99 [95%CI, 1.38-2.88]; GNRI 92-98 HR = 1.51 [95%CI, 1.04-2.18]) but not with nutritional status by the MNA. A significant association was also found with cardiovascular mortality (GNRI <92 HR = 1.79 [95%CI, 1.23-2.61]).
Nutritional risk by GNRI but not nutritional status by MNA was associated with higher mortality risk. Present data suggest that in the nutritional screening of newly institutionalised elderly the use of the GNRI should be preferred to that of the MNA.
有多种工具可用于营养筛查。我们评估了新入院的老年患者中,老年营养风险指数(GNRI)和微型营养评估(MNA)与死亡率的相关性。
这是一项前瞻性观察性研究,共纳入 358 名新入住长期护理机构的老年人。通过多变量 Cox 模型估计 GNRI 分类和 MNA 分类的死亡率风险比(HR)。
在基线时,32.4%和 37.4%的患者分别被归类为营养不良(MNA<17)和严重营养风险(GNRI<92),而分别有 57.5%和 35.2%的患者被归类为有营养不良风险(MNA 17-23.5)和低营养风险(GNRI 92-98)。在中位随访 6.5 年(25 至 75 百分位数,5.9 至 8.6)期间,有 297 名老年人死亡。所有原因死亡率的风险与 GNRI 工具评估的营养风险显著相关(GNRI<92 HR=1.99[95%CI,1.38-2.88];GNRI 92-98 HR=1.51[95%CI,1.04-2.18]),但与 MNA 评估的营养状况无关。与心血管死亡率也存在显著相关性(GNRI<92 HR=1.79[95%CI,1.23-2.61])。
GNRI 评估的营养风险,而不是 MNA 评估的营养状况,与更高的死亡率风险相关。目前的数据表明,在新入院的老年患者的营养筛查中,应优先使用 GNRI 而不是 MNA。