Tarn A C, Thomas J M, Drury P L
Department of Diabetes and Immunogenetics, Medical College of St Bartholomew's Hospital, London, UK.
J Hypertens. 1990 Sep;8(9):795-803. doi: 10.1097/00004872-199009000-00002.
We compared the correlates of blood pressure in 163 young patients with insulin-dependent diabetes and in 232 of their non-diabetic siblings. A single observer recorded blood pressure in all subjects, plus all their available parents, using a standardized technique. Other variables recorded included age, weight, height, presence of diabetes and urinary albumin. The major factors accounting for over 50% of the variance of systolic blood pressure (SBP) in both groups were age, weight, paternal SBP and sex. In addition, in the diabetic group the logarithm of the random urinary albumin concentration was a significant explanatory variable. For diastolic blood pressure (DBP) approximately 16% of the variance was explained by age, weight and maternal DBP. Parental blood pressure was an important determinant of blood pressure in both the diabetic and non-diabetic sibling groups. The similarity of the correlates of blood pressure in the two groups suggests that the determinants of blood pressure in young insulin-dependent diabetic patients and in the general population are similar.
我们比较了163例胰岛素依赖型糖尿病年轻患者及其232名非糖尿病兄弟姐妹的血压相关因素。由一名观察者使用标准化技术记录所有受试者及其所有在世父母的血压。记录的其他变量包括年龄、体重、身高、糖尿病患病情况和尿白蛋白。在两组中，年龄、体重、父亲的收缩压（SBP）和性别是解释收缩压（SBP）超过50%变异的主要因素。此外，在糖尿病组中，随机尿白蛋白浓度的对数是一个显著的解释变量。对于舒张压（DBP），约16%的变异由年龄、体重和母亲的舒张压解释。父母的血压是糖尿病组和非糖尿病兄弟姐妹组血压的重要决定因素。两组血压相关因素的相似性表明，年轻胰岛素依赖型糖尿病患者和普通人群中血压的决定因素相似。
