儿童桡骨远端和胫骨的骨密度和微观结构特性的精确性：一项 HR-pQCT 研究。
Precision of bone density and micro-architectural properties at the distal radius and tibia in children: an HR-pQCT study.
机构信息
Department of Mechanical Engineering, College of Engineering, University of Saskatchewan, 57 Campus Drive, Saskatoon, SK, S7N 5A9, Canada.
College of Kinesiology, University of Saskatchewan, 87 Campus Drive, Saskatoon, SK, S7N 5B2, Canada.
出版信息
Osteoporos Int. 2017 Nov;28(11):3189-3197. doi: 10.1007/s00198-017-4185-y. Epub 2017 Sep 18.
UNLABELLED
Precision errors need to be known when monitoring bone micro-architecture in children with HR-pQCT. Precision errors for trabecular bone micro-architecture ranged from 1 to 8% when using the standard evaluation at the radius and tibia. Precision errors for cortical bone micro-architecture ranged from 1 to 11% when using the advanced cortical evaluation.
INTRODUCTION
Our objective was to define HR-pQCT precision errors (CV%) and least significant changes (LSCs) at the distal radius and tibia in children using the standard evaluation and the advanced cortical evaluation.
METHODS
We scanned the distal radius (7% of ulnar length) and tibia (8% of tibia length) of 32 children (age range 8-13; mean age 11.3; SD 1.6 years) twice (1 week apart) using HR-pQCT (XtremeCT1). We calculated root-mean-squared coefficients of variation (CV%) to define precision errors and LSC to identify differences required to detect change.
RESULTS
Precision errors ranged between 1-8 and 1-5% for trabecular bone outcomes (obtained with standard evaluation) and between 1.5-11 and 0.5-6% for cortical bone outcomes (obtained with advanced cortical evaluation) at the distal radius and tibia, respectively. Related LSCs ranged between 3-21 and 3-14% for trabecular bone outcomes and between 4-30 and 2-16% for cortical bone outcomes at the distal radius and tibia, respectively.
CONCLUSIONS
HR-pQCT precision errors were between 1 and 8% (LSC 3-21%) for trabecular bone outcomes and 1 and 11% (LSC 2-30%) for cortical bone outcomes at the radius and tibia in children. Cortical bone outcomes obtained using the advanced cortical evaluation appeared to have lower precision errors than cortical outcomes derived using the standard evaluation. These findings, combined with better-defined cortical bone contours with advanced cortical evaluation, indicate that metrics from advanced cortical evaluation should be utilized when monitoring cortical bone properties in children.
未加标签
在使用高分辨率 CT（HR-pQCT）监测儿童骨微观结构时，需要了解精密度误差。当使用桡骨和胫骨的标准评估时，小梁骨微观结构的精密度误差范围为 1%至 8%。当使用高级皮质评估时，皮质骨微观结构的精密度误差范围为 1%至 11%。
引言
我们的目标是使用标准评估和高级皮质评估，在儿童的桡骨远端和胫骨处定义 HR-pQCT 精密度误差（CV%）和最小有意义变化（LSC）。
方法
我们使用高分辨率 CT（XtremeCT1）对 32 名儿童（年龄 8-13 岁；平均年龄 11.3 岁；标准差 1.6 岁）的桡骨远端（尺骨长度的 7%）和胫骨远端（胫骨长度的 8%）进行了两次扫描（间隔 1 周）。我们计算了均方根变异系数（CV%）以定义精密度误差，并计算了最小有意义变化（LSC）以确定检测变化所需的差异。
结果
在桡骨和胫骨远端，使用标准评估获得的小梁骨结果的精密度误差范围为 1%-8%和 1%-5%，使用高级皮质评估获得的皮质骨结果的精密度误差范围为 1.5%-11%和 0.5%-6%。分别为。相关的 LSC 范围为桡骨和胫骨远端的 3%-21%和 3%-14%，用于小梁骨结果和 4%-30%和 2%-16%，用于皮质骨结果。
结论
在儿童的桡骨和胫骨处，使用标准评估获得的小梁骨结果的 HR-pQCT 精密度误差范围为 1%-8%（LSC 为 3%-21%），使用高级皮质评估获得的皮质骨结果的精密度误差范围为 1%-11%（LSC 为 2%-30%）。使用高级皮质评估获得的皮质骨结果似乎比使用标准评估获得的皮质骨结果具有更低的精密度误差。这些发现，加上高级皮质评估更好地定义了皮质骨轮廓，表明在监测儿童皮质骨特性时应利用高级皮质评估的指标。
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