Choo Y C, Seto W H, Hsu C, Merigan T C, Tan Y H, Ma H K, Ng M H
Br J Obstet Gynaecol. 1986 Apr;93(4):372-9.
Twelve patients with cervical intraepithelial neoplasia (CIN) were studied by colposcopy and cervical smears to elucidate the local response to interferon alpha and beta given by perilesional injections and to assess long-term disease remission. In all patients, local inflammatory response was seen and persisted throughout the treatment period. Selective toxic effect was evident by exfoliation of increasing proportion of degenerate to viable dyskaryotic cells, while the normal epithelial cells appeared unaffected, and by the progressive regression of the lesion. Interferon alpha induced complete remission in six of seven (85.7%) patients but three had recurrence 12 to 24 months later, while interferon beta induced complete remission in only two of five (40%) patients.
通过阴道镜检查和宫颈涂片对12例宫颈上皮内瘤变（CIN）患者进行研究，以阐明病灶周围注射α干扰素和β干扰素后的局部反应，并评估疾病的长期缓解情况。所有患者均出现局部炎症反应，且在整个治疗期间持续存在。通过退变的异常核型细胞与活的异常核型细胞比例增加以及正常上皮细胞未受影响，同时病变逐渐消退，可明显看出选择性毒性作用。α干扰素使7例患者中的6例（85.7%）完全缓解，但3例在12至24个月后复发，而β干扰素仅使5例患者中的2例（40%）完全缓解。
