Dezzutti C S, Frazier D E, Lafrado L J, Olsen R G
Department of Veterinary Pathobiology, Ohio State University, Columbus.
J Med Primatol. 1990;19(3-4):305-16.
Pig-tailed macaques were vaccinated with a human T-cell lymphotropic virus type I (HTLV-I) subunit vaccine. Vaccinates and controls were challenged with simian T-cell lymphotropic virus type I (STLV-I)-infected cells. Vaccination yielded antibody responses to HTLV-I and STLV-I gag and env precursors. Controls developed HTLV-I and STLV-I antibody to gag and tax protein. Immunization produced syncytium inhibiting antibody and cellular cytotoxicity to virus-infected cells. Reverse transcriptase activity was present in control macaques only, implying that the subunit vaccine was protective against STLV-I infection.
将猪尾猕猴用人类I型嗜T细胞病毒（HTLV-I）亚单位疫苗进行接种。对接种疫苗的猕猴和对照猕猴用感染了猿猴I型嗜T细胞病毒（STLV-I）的细胞进行攻击。接种疫苗产生了针对HTLV-I和STLV-I gag及env前体的抗体反应。对照猕猴产生了针对gag和tax蛋白的HTLV-I和STLV-I抗体。免疫产生了抑制合胞体的抗体以及对病毒感染细胞的细胞毒性。仅在对照猕猴中检测到逆转录酶活性，这表明亚单位疫苗对STLV-I感染具有保护作用。
