一氧化氮和环鸟苷酸信号通路作为药物研发的重点。
Nitric oxide and cyclic GMP signaling pathway as a focus for drug development.
机构信息
Department of Biochemistry and Molecular Biology, George Washington University School of Medicine, 2300 Eye Street NW, Ross Hall 530, Washington DC 20052, USA.
出版信息
Curr Med Chem. 2011;18(22):3299-305. doi: 10.2174/092986711796504646.
PMID:21728973
Abstract
Recent progress in understanding of the nitric oxide and cGMP signaling pathway provided evidence for mechanism of action of known drugs and identified novel targets for drug development. These discoveries resulted in numerous efforts in drug and formulation discovery. Some of the most promising approaches were applied for efficient therapies of various diseases.
摘要
近年来，人们对一氧化氮和 cGMP 信号通路的认识不断深入，为已知药物的作用机制提供了证据，并确定了药物开发的新靶点。这些发现促使人们在药物和制剂发现方面进行了大量努力。一些最有前途的方法已应用于各种疾病的有效治疗。
Zotero 插件