Research Center, Nano Intelligent Biomedical Engineering Corporation, College of Dentistry, Seoul National University, 28-22 Yongon-Dong, Chongno-Ku, Seoul 110-749, South Korea.
Curr Pharm Des. 2011;17(25):2663-76. doi: 10.2174/138161211797416011.
Bioactive biomaterials are desirable as tissue engineering scaffolds by virtue of their capability to mimic the natural environment of the extracellular matrix. Bioactive biomaterials have been achieved by incorporating synthetic short peptide sequences into suitable materials either by surface modification or by bulk incorporation. The goal is to enhance cell attachment and other basic functions. Bioactive peptides can be obtained from biological or chemically synthesized sources, increasing their specific cellular responses for tissue growth and development. Compared to using an entire growth factor in regenerative therapy, these peptides demonstrate potential advantages such as overcoming possible immunogenicity, being less susceptible to degradation, and producing fewer tumor-related side effects. Biomaterial scaffolds modified with peptides can provide biological ligands for cell-scaffold interactions that promote cell attachment, proliferation, and differentiation. Peptide-based biomaterial scaffolds can be fabricated to form two- and three-dimensional structures. This review discusses cell-binding, biominerailization inducing peptides, and receptor-binding peptides for bone regeneration. This review also addresses issues related to peptide immobilization as well as potential complications that may develop as a result of using these versatile bioactive peptides. The development of self-assembled peptide amphiphiles with the goal of generating new three-dimensional scaffolds for tissue engineering is also summarized.
生物活性生物材料因其能够模拟细胞外基质的自然环境而被视为组织工程支架的理想材料。通过将合成短肽序列整合到合适的材料中，可以通过表面修饰或整体掺入来实现生物活性生物材料。目的是增强细胞附着和其他基本功能。生物活性肽可以从生物或化学合成来源获得，从而增加其对组织生长和发育的特定细胞反应。与在再生治疗中使用整个生长因子相比，这些肽具有潜在的优势，例如克服可能的免疫原性、不易降解以及产生较少的与肿瘤相关的副作用。用肽修饰的生物材料支架可以为促进细胞附着、增殖和分化的细胞-支架相互作用提供生物配体。基于肽的生物材料支架可以被制造为形成二维和三维结构。本文综述了用于骨再生的细胞结合、生物矿化诱导肽和受体结合肽。本文还讨论了与肽固定化相关的问题以及由于使用这些多功能生物活性肽而可能产生的潜在并发症。还总结了具有生成用于组织工程的新三维支架的目的的自组装肽两亲物的发展。
