亚甲基四氢叶酸还原酶 C677T 多态性与南印度人群男性不育症无关。
Methylenetetrahydrofolate reductase C677T polymorphism is not associated with male infertility in a South Indian population.
机构信息
Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Hyderabad, India.
出版信息
Andrologia. 2012 May;44 Suppl 1:252-9. doi: 10.1111/j.1439-0272.2011.01172.x. Epub 2011 Jul 6.
Previous studies have revealed that genetic factors may be involved in regulating the mechanism of infertility, e.g., MTHFR gene polymorphism in the development of male infertility. The aim of this study is to examine whether an association exists between MTHFR C677T polymorphism and male infertility. The study was carried out by means of a PCR-RFLP assay in 206 infertile men and 230 ethnically matched controls. The statistical analysis using two-sided Fisher's exact test and Pearson chi-squared test showed CT genotype is associated nonsignificantly with male infertility (OR = 1.19, 95% CI = 0.71-1.97). Because of the lack of TT homozygotes in the controls, a combined odds ratio of CT and TT homozygotes against the control has been calculated (OR = 1.36, 95% CI = 0.83-2.22), and the same was insignificant. The overall results of the study indicate that MTHFR C677T polymorphism is not associated with male infertility.
先前的研究表明，遗传因素可能参与调节不孕的机制，例如 MTHFR 基因多态性与男性不育的发展有关。本研究旨在探讨 MTHFR C677T 多态性与男性不育之间是否存在关联。该研究通过聚合酶链反应-限制性片段长度多态性分析（PCR-RFLP）在 206 名不育男性和 230 名种族匹配的对照中进行。使用双侧 Fisher 精确检验和 Pearson χ2 检验的统计分析显示，CT 基因型与男性不育无显著相关性（OR = 1.19，95%CI = 0.71-1.97）。由于对照组中缺乏 TT 纯合子，因此计算了 CT 和 TT 纯合子与对照组的合并优势比（OR = 1.36，95%CI = 0.83-2.22），同样无统计学意义。该研究的总体结果表明，MTHFR C677T 多态性与男性不育无关。
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