Department of Histology, University of Padova, Padova, Italy.
Diabetes Care. 2011 Aug;34(8):1875-7. doi: 10.2337/dc11-0070. Epub 2011 Jul 5.
To study the relation between metabolic syndrome (MS), cavernosal morphological vasculopathy, and peripheral vascular alterations (carotid and femoral wall) in patients with erectile dysfunction.
A total of 207 patients and 50 control subjects were evaluated for cardiovascular risk factors, physical examination, reproductive hormones, ultrasound analysis of cavernosal, carotid and femoral arteries (intima-media thickness), and cavernosal flow measurement (peak systolic velocity).
A total of 28% of patients had MS, and they presented with a high prevalence of cavernosal alterations (70.3%) and systemic vascular impairment (59.3%), whereas patients with cavernosal alterations (44%) showed the higher prevalence of MS (48.9%). The number of MS components was related to the prevalence of penile vasculopathy. However, multivariate analysis showed that MS is not an independent predictor for cavernosal vasculopathy.
Patients with cavernosal vasculopathy have an increased cardiometabolic risk, and screening for MS components might identify individuals with a higher risk for cavernosal and systemic atherosclerosis.
研究勃起功能障碍患者代谢综合征（MS）、海绵体形态血管病变与外周血管改变（颈动脉和股动脉壁）之间的关系。
共评估了 207 例患者和 50 例对照者的心血管危险因素、体格检查、生殖激素、海绵体、颈动脉和股动脉超声分析（内膜中层厚度）以及海绵体血流测量（收缩期峰值速度）。
28%的患者患有 MS，他们表现出较高的海绵体改变（70.3%）和全身血管损伤（59.3%），而存在海绵体改变的患者（44%）MS 的患病率更高（48.9%）。MS 成分的数量与阴茎血管病变的患病率有关。然而，多变量分析显示 MS 不是海绵体血管病变的独立预测因素。
存在海绵体血管病变的患者存在更高的心脏代谢风险，筛查 MS 成分可能有助于确定存在更高的海绵体和全身动脉粥样硬化风险的个体。
