Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 2969, Durham, NC 27710, USA.
Hypertension. 2011 Aug;58(2):161-6. doi: 10.1161/HYPERTENSIONAHA.111.171272. Epub 2011 Jul 5.
In the National Longitudinal Study of Adolescent Health, a US longitudinal study of >15 000 young adults, we examined the extent to which socioeconomic status is linked to systolic blood pressure (SBP) and whether biobehavioral risk factors mediate the association. More than 62% of the participants had SBP >120 mm Hg and 12% had SBP >140 mm Hg. More than 66% were classified as at least overweight (body mass index >25 kg/m(2)), with >36% meeting criteria for at least class I obesity (body mass index >30 kg/m(2)). Multivariate models showed that higher household income and being married were independently associated with lower SBP. Higher body mass index, greater waist circumference, smoking, and higher alcohol intake were each independently associated with higher SBP. Meditational analyses suggested that higher education level was associated with lower SBP by way of lower body mass, smaller waist circumference, and lower resting heart rate. When these indirect effects were accounted for, education was not significantly associated with SBP. In contrast, household income remained associated with SBP even with control for all of the covariates. Results reinforce current public health concerns about rates of obesity and high blood pressure among young adults and suggest that disparities in education level and household income may play an important role in the observed decrements in health. Identifying modifiable mechanisms that link socioeconomic status to SBP using data from a large representative sample may improve risk stratification and guide the development of effective interventions.
在美国青少年健康纵向研究(一项针对超过 15000 名年轻人的美国纵向研究)中,我们考察了社会经济地位与收缩压(SBP)之间的关联程度,以及生物行为风险因素是否在其中起中介作用。超过 62%的参与者收缩压 >120mmHg,12%的参与者收缩压 >140mmHg。超过 66%的参与者被归类为至少超重(体重指数 >25kg/m2),超过 36%的参与者符合至少 I 级肥胖标准(体重指数 >30kg/m2)。多变量模型显示,较高的家庭收入和已婚状况与较低的 SBP 独立相关。较高的体重指数、较大的腰围、吸烟和较高的酒精摄入量与较高的 SBP 独立相关。中介分析表明,较高的教育水平与较低的 SBP 相关,途径是较低的体重、较小的腰围和较低的静息心率。当考虑到这些间接效应时,教育与 SBP 之间就不再显著相关。相比之下,即使控制了所有协变量,家庭收入仍然与 SBP 相关。研究结果强化了当前公众对年轻人中肥胖和高血压发病率的担忧,并表明教育水平和家庭收入方面的差异可能在观察到的健康状况下降中起着重要作用。使用来自大型代表性样本的数据,确定将社会经济地位与 SBP 联系起来的可改变机制,可能会改善风险分层,并指导有效干预措施的制定。