Babu P Suresh, Krishna V, Maruthi K R, Shankarmurthy K, Babu Ramesh K
Phytochemistry and Pharmacology Laboratory, Department of Post Graduate Studies and Research in Biotechnology and Bioinformatics, School of Biological Sciences, Kuvempu University, Shankaraghatta - 577 451, India.
Pharmacognosy Res. 2011 Jan;3(1):40-3. doi: 10.4103/0974-8490.79114.
D. cinerea are the chief source of drug compounds that are active against various ailments such as jaundice, inflammations rheumatism, fever, asthma, body ache, chest problems, toothache, ulcers, wounds, eye diseases and have an aphrodisiac property. In present study, It was aimed to test the hepatoprotective activity of the plant.
The methanolic extract of Dichrostachys cinerea (Mimoseae) leaves was subjected to evaluation of acute toxicity and hepatoprotective property, using albino mice and rats. The parameters for estimation of liver function, based on serum markers such as total bilirubin, total protein, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase with histopathological profile of the liver tissue, were studied consequently.
The methanolic extract did not show any mortality up to a dose of 3500 mg/kg body weight. The methanolic extract showed significant hepatoprotectivity. The histopathological profile of the drug-treated liver tissue demonstrated similar morphology as that of controls.
Methanolic extract of Dichrostachys cinerea was found to have significant hepatoprotective activity.
灰毛相思树是具有抗多种疾病活性的药物化合物的主要来源，这些疾病包括黄疸、炎症、风湿、发烧、哮喘、身体疼痛、胸部问题、牙痛、溃疡、伤口、眼部疾病，并且具有壮阳特性。在本研究中，旨在测试该植物的肝保护活性。
使用白化病小鼠和大鼠，对灰毛相思树（含羞草科）叶的甲醇提取物进行急性毒性和肝保护特性评估。随后研究了基于血清标志物如总胆红素、总蛋白、丙氨酸转氨酶、天冬氨酸转氨酶、碱性磷酸酶以及肝组织组织病理学特征的肝功能评估参数。
甲醇提取物在高达3500mg/kg体重的剂量下未显示任何死亡情况。甲醇提取物显示出显著的肝保护作用。药物处理的肝组织的组织病理学特征显示出与对照相似的形态。
发现灰毛相思树的甲醇提取物具有显著的肝保护活性。
