Division of Pediatric Oncology/Hematology, Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, The Netherlands.
J Membr Biol. 2011 Jul;242(2):69-74. doi: 10.1007/s00232-011-9381-7. Epub 2011 Jul 6.
Membrane proteins are involved in the prognosis of the most common forms of cancer. Membrane proteins are the hallmark of a cancer cell. The overexpressed membrane receptors are becoming increasingly important in cancer cell therapy. Current renewing therapy approaches based on receptor overexpression include; antibody therapy, nanocarrier drug delivery, and fluorescent tumor imaging in surgery. Gene profiling reveals cancer specific signatures and may identify membrane proteins that are related to cancer progression and lead to the development of improved therapy strategies in the future.
膜蛋白参与最常见癌症形式的预后。膜蛋白是癌细胞的标志。过表达的膜受体在癌细胞治疗中变得越来越重要。目前基于受体过表达的更新治疗方法包括：抗体治疗、纳米载体药物递送和手术中的荧光肿瘤成像。基因谱分析揭示了癌症特异性特征，并可能确定与癌症进展相关的膜蛋白，从而为未来开发改进的治疗策略提供依据。
