Sahinduran Sima, Albay Metin Koray, Sezer Kenan, Ozmen Ozlem, Mamak Nuri, Haligur Mehmet, Karakurum Cagri, Yildiz Ramazan
Department of Internal Medicine, Faculty of Veterinary Medicine, University of Mehmet, Akif Ersoy, Burdur, Turkey.
Trop Anim Health Prod. 2012 Mar;44(3):453-7. doi: 10.1007/s11250-011-9917-y. Epub 2011 Jul 6.
The aim of this study was to examine the coagulation profile in peste des petits ruminant (PPR) in kids. Five kids from a group of 150 animals (72 goats and 78 kids) were brought to the Veterinary Medical Teaching Hospital from a farm in Burdur province (Turkey) with nasal and ocular discharges and diarrhea. Fifteen goats and 41 kids had died due to diarrhea and three kids were presented to the Department of Pathology for diagnosis. Blood samples were taken from 12 ill animals (infected group) for haematological and biochemical analysis. In addition, five healthy kids were examined from another healthy flock (control group). Leukocyte and lymphocyte numbers of infected group showed significant declinations in comparison to control group (≤0.001). Haemorrhages in all organs of digestive system and small haemorrhagic areas in liver were caused to decrease in erythrocyte and haematocrit values (p ≤ 0.001) in infected group. Concentrations of blood urea nitrogen (BUN) (p ≤ 0.01) and creatinine (p ≤ 0.001) in infected group were significantly higher than control group. Compared to control group, significant increases were determined in serum concentrations of alkaline phosphatase (ALP) (p ≤ 0.01), aspartate aminotransferase (AST) (p ≤ 0.001) and alanine aminotransferase (ALT) (p ≤ 0.001) in the infected group. No significant differences were observed between the infected and control groups for serum gamma glutamyl-transferase (GGT) concentration value. In our study, thrombocytopenia (p ≤ 0.001) together with prolonged activated partial thromboplastin time (APTT; p ≤ 0.01) and prothrombin time (PT; p ≤ 0.001) may show that disseminated intravascular coagulopathy which can occur in kids with PPR.
本研究的目的是检测幼羊感染小反刍兽疫（PPR）后的凝血指标。从布尔杜尔省（土耳其）一个农场的150只动物（72只山羊和78只幼羊）中挑选出5只出现鼻眼分泌物和腹泻症状的幼羊，送至兽医医学教学医院。15只山羊和41只幼羊因腹泻死亡，3只幼羊被送到病理科进行诊断。采集了12只患病动物（感染组）的血液样本进行血液学和生化分析。此外，从另一个健康羊群中挑选了5只健康幼羊作为对照组进行检查。与对照组相比，感染组的白细胞和淋巴细胞数量显著下降（≤0.001）。感染组消化系统所有器官的出血以及肝脏中的小出血区域导致红细胞和血细胞比容值降低（p≤0.001）。感染组的血尿素氮（BUN）浓度（p≤0.01）和肌酐浓度（p≤0.001）显著高于对照组。与对照组相比，感染组血清碱性磷酸酶（ALP）（p≤0.01）、天冬氨酸转氨酶（AST）（p≤0.001）和丙氨酸转氨酶（ALT）（p≤0.001）的浓度显著升高。感染组和对照组的血清γ-谷氨酰转移酶（GGT）浓度值无显著差异。在我们的研究中，血小板减少（p≤0.001）以及活化部分凝血活酶时间延长（APTT；p≤0.01）和凝血酶原时间延长（PT；p≤0.001）可能表明感染PPR的幼羊会发生弥散性血管内凝血。
