Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine of University of Southern California, Los Angeles, California 90033, USA.
Br J Ophthalmol. 2012 Mar;96(3):380-5. doi: 10.1136/bjo.2010.201111. Epub 2011 Jul 6.
BACKGROUND/AIMS: To compare retinal thickness measurements from three different spectral domain optical coherence instruments when manual segmentation is employed to standardise retinal boundary locations.
40 eyes of 21 healthy subjects were scanned on the Cirrus HD-OCT, Topcon 3D-OCT-2000 and Heidelberg Spectralis-OCT. Raw data were imported into custom grading software (3D-OCTOR). Manual segmentation was performed on every data set, and retinal thickness values in the foveal central subfield were computed.
37 eyes of 20 subjects were gradable on every machine. The average retinal thicknesses for these eyes were 236.7 μm (SD 20.1), 235.7 μm (SD 20.4) and 236.5 μm (SD 18.0) for the Cirrus, 3D-OCT-2000 and Spectralis, respectively. Comparing manual retinal thickness measurements between any two machines, the maximum difference was 18.2 μm. The mean absolute differences per eye between two machines were: 4.9 μm for Cirrus versus 3D-OCT-2000, 3.7 μm for Cirrus versus Spectralis and 4.4 μm for 3D-OCT-2000 versus Spectralis.
When a uniform position is used to locate the outer retinal boundary, the retinal thickness measurements derived from three different spectral domain optical coherence instruments devices are virtually identical. Manual correction may allow OCT-derived thickness measurements to be compared between devices in clinical trials and clinical research.
背景/目的：比较三种不同的谱域光相干断层扫描仪在采用手动分割以标准化视网膜边界位置时的视网膜厚度测量值。
21 名健康受试者的 40 只眼分别在 Cirrus HD-OCT、Topcon 3D-OCT-2000 和 Heidelberg Spectralis-OCT 上进行扫描。原始数据被导入定制的分级软件（3D-OCTOR）。对每个数据集进行手动分割，并计算中心凹中央子区的视网膜厚度值。
20 名受试者中有 37 只眼可以在每台机器上分级。这些眼睛的平均视网膜厚度分别为 236.7μm（SD 20.1）、235.7μm（SD 20.4）和 236.5μm（SD 18.0），分别来自 Cirrus、3D-OCT-2000 和 Spectralis。比较任意两台机器之间的手动视网膜厚度测量值，最大差异为 18.2μm。两台机器之间每只眼睛的平均绝对差异分别为：Cirrus 与 3D-OCT-2000 之间为 4.9μm，Cirrus 与 Spectralis 之间为 3.7μm，3D-OCT-2000 与 Spectralis 之间为 4.4μm。
当使用统一的位置来定位外视网膜边界时，来自三种不同的谱域光相干断层扫描仪设备的视网膜厚度测量值几乎完全相同。手动校正可能允许在临床试验和临床研究中比较 OCT 衍生的厚度测量值。
