Department of Ophthalmology, Jeju National University College of Medicine, Jeju, South Korea.
Department of Ophthalmology, Korea University College of Medicine, Seoul, South Korea.
Sci Rep. 2024 Feb 12;14(1):3560. doi: 10.1038/s41598-024-54109-6.
We sought to compare the retinal thickness measurements collected using different optical coherence tomography (OCT) devices. This prospective study included 21 healthy cases, and the retinal thickness was measured using the PLEX Elite (Carl Zeiss Meditec, Dublin, California, USA), DRI OCT-1 Atlantis (Topcon Corp, Tokyo, Japan), Cirrus 5000 HD-OCT (Carl Zeiss Meditec), and Spectralis OCT (Heidelberg Engineering, Heidelberg, Germany), respectively. The mean central retinal thickness (CRT) and mean retinal thickness of the Early Treatment of Diabetic Retinopathy Study (ETDRS) area were compared. The CRT varied significantly among the different OCT devices (P < 0.001). Post-hoc analysis revealed that the CRT measured using PLEX Elite (278.95 ± 20.04 µm) and Spectralis (271.86 ± 17.92 µm) were similar, and both were greater than the CRT measurements of DRI OCT-1 (239.57 ± 21.06 µm) and Cirrus (256.76 ± 17.82 µm). Additionally, the mean retinal thickness in each ETDRS area showed significant differences among the four devices (all P < 0.001). The mean retinal thickness measured varied according to the device used, and this needs to be considered when comparing retinal thickness measurements taken with different devices.
我们旨在比较不同光学相干断层扫描（OCT）设备采集的视网膜厚度测量值。这项前瞻性研究纳入了 21 例健康病例，分别使用 PLEX Elite（卡尔蔡司医疗技术公司，加利福尼亚州都柏林）、DRI OCT-1 Atlantis（拓普康公司，东京）、Cirrus 5000 HD-OCT（卡尔蔡司医疗技术公司）和 Spectralis OCT（海德堡工程公司，海德堡）进行视网膜厚度测量。比较了平均中心视网膜厚度（CRT）和糖尿病视网膜病变早期治疗研究（ETDRS）区域的平均视网膜厚度。不同 OCT 设备的 CRT 差异有统计学意义（P<0.001）。事后分析显示，PLEX Elite（278.95±20.04µm）和 Spectralis（271.86±17.92µm）测量的 CRT 相似，均大于 DRI OCT-1（239.57±21.06µm）和 Cirrus（256.76±17.82µm）的 CRT 测量值。此外，四个设备之间每个 ETDRS 区域的平均视网膜厚度均有显著差异（均 P<0.001）。不同设备测量的平均视网膜厚度存在差异，因此在比较不同设备获得的视网膜厚度测量值时需要考虑这一点。
