Gökmen Onur, Yeşilırmak Nilüfer, Akman Ahmet, Gür Güngör Sirel, Yücel Ahmet Eftal, Yeşil Hilmi, Yıldız Fatih, Sise Adam, Diakonis Vasilios
University of Health Sciences, Van Training and Research Hospital, Department of Ophthalmology, Van, Turkey.
University of Health Sciences, Ankara Training and Research Hospital, Department of Ophthalmology, Ankara, Turkey.
Turk J Ophthalmol. 2017 Dec;47(6):315-319. doi: 10.4274/tjo.58712. Epub 2017 Dec 25.
To investigate corneal, scleral, choroidal, and foveal thicknesses in female patients with rheumatoid arthritis (RA) and compare them with healthy subjects.
This prospective study included consecutive female patients diagnosed with RA and healthy subjects. Corneal, scleral, choroidal, and retinal (foveal) thicknesses were obtained by using optical coherence tomography and a comparison was performed between groups for all outcome measures.
Thirty-six eyes of 36 female patients diagnosed with RA (group 1) and 36 eyes of 36 healthy female volunteers (group 2) were included. Mean corneal, scleral, choroidal thicknesses and retinal thickness at the fovea of group 1 were 543.3±33.7 µm, 343.7±42.2 µm, 214.6±50, and 213.5±18.9 µm, respectively; in group 2, these values were 549.9±29.6 μm, 420.9±42.4 μm, 206.4±41.9 μm, and 222±15.5 μm, respectively. The comparison between group 1 and 2 with respect to corneal, choroidal, and foveal thicknesses did not reveal statistical significant differences (p>0.05). On the contrary, there was a statistically significant difference with respect to scleral thickness between the groups, with the RA patients demonstrating a thinner scleral layer (p<0.001).
Female patients with RA seem to demonstrate statistically significant scleral thinning when compared with healthy subjects, while there was no difference concerning corneal, choroidal, and foveal thickness.
研究类风湿关节炎（RA）女性患者的角膜、巩膜、脉络膜和黄斑厚度，并与健康受试者进行比较。
这项前瞻性研究纳入了连续诊断为RA的女性患者和健康受试者。使用光学相干断层扫描获取角膜、巩膜、脉络膜和视网膜（黄斑）厚度，并对所有结果指标进行组间比较。
纳入了36例诊断为RA的女性患者的36只眼（第1组）和36名健康女性志愿者的36只眼（第2组）。第1组的平均角膜、巩膜、脉络膜厚度和黄斑处视网膜厚度分别为543.3±33.7 µm、343.7±42.2 µm、214.6±50 µm和213.5±18.9 µm；第2组的这些值分别为549.9±29.6 µm、420.9±42.4 µm、206.4±41.9 µm和222±15.5 µm。第1组和第2组在角膜、脉络膜和黄斑厚度方面的比较未显示出统计学显著差异（p>0.05）。相反，两组之间在巩膜厚度方面存在统计学显著差异，RA患者的巩膜层较薄（p<0.001）。
与健康受试者相比，RA女性患者似乎表现出统计学显著的巩膜变薄，而在角膜、脉络膜和黄斑厚度方面没有差异。
