Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Ophthalmology. 2012 Nov;119(11):2319-27. doi: 10.1016/j.ophtha.2012.07.012. Epub 2012 Sep 19.
To investigate the reproducibility of imaging the foveal microstructures of healthy eyes with 3 spectral domain optical coherence tomography (SD-OCT) machines: Cirrus (Carl Zeiss Meditec Inc.), Spectralis (Heidelberg Engineering), and Topcon (Topcon 3D OCT-1000 Mark II).
Cross-sectional, prospective, noninterventional study.
Images were obtained for 50 eyes of 50 healthy undilated volunteers without ocular pathology in a clinical setting.
The fovea of all subjects was imaged using Cirrus, Spectralis, and Topcon.
Among the 4 hyperreflective bands in the outer subfovea on SD-OCT imaging, the innermost band (external limiting membrane [ELM] band), the second innermost band (second band), and the third innermost band (third band) were classified as "continuous," "disrupted," or "none" by 2 independent raters. Weighted κ-coefficient analysis and/or Fisher exact test were used to compare interrater, intermachine, and intramachine agreement measurements. The sensitivity of each machine was also evaluated.
The group of 50 subjects consisted of 22 men and 28 women, with an average age of 31.4 years (range, 21-52 years). Interrater agreement for 3 bands was high (κ = 0.876, 0.738, and 0.774) with Cirrus, Spectralis, and Topcon, respectively. The sensitivity of each machine was high for the ELM band (0.92, 0.98, and 0.96), the second band (all 1.00), and the third band (0.96, 0.94, and 0.88) with Cirrus, Spectralis, and Topcon, respectively. The sensitivity of the third band was significantly lower than the second band with Topcon (Fisher exact test, P = 0.027), but the difference was not significant with the other machines. Intermachine agreement was fair to moderate for the third band (κ = 0.65, 0.512, and 0.464) and for all bands (κ = 0.531, 0.369, and 0.362) between Cirrus-Spectralis, Spectralis-Topcon, and Topcon-Cirrus, respectively; however, it was not significant for ELM band (κ = -0.027) between Spectralis-Topcon.
In healthy adults with normal vision, there was almost perfect reproducibility between raters for foveal microstructural images acquired with the Cirrus, Spectralis, and Topcon devices. The machines have good sensitivity to image foveal microstructures, and the sensitivity does not differ significantly among machines; however, they are not necessarily identical or interchangeable for imaging certain structures.
研究 3 种谱域光学相干断层扫描（SD-OCT）仪（Cirrus [卡尔蔡司医学技术公司]、Spectralis [海德堡工程公司]和 Topcon [拓普康 3D OCT-1000 Mark II]）对健康人眼的黄斑微结构成像的可重复性。
横断面、前瞻性、非干预性研究。
在临床环境中，对 50 名无眼部病变的健康未散瞳志愿者的 50 只眼进行了图像采集。
对所有受检者的黄斑均进行 Cirrus、Spectralis 和 Topcon 扫描。
在 SD-OCT 成像的外下黄斑区的 4 个高反射带中，最内层带（外界膜[ELM]带）、第二内层带（第二带）和第三内层带（第三带）由 2 位独立评分者分类为“连续”、“中断”或“无”。采用加权κ系数分析和/或 Fisher 确切检验比较评分者间、机器间和机器内的一致性测量值。还评估了每种仪器的敏感性。
50 名受检者中包括 22 名男性和 28 名女性，平均年龄为 31.4 岁（范围：21-52 岁）。Cirrus、Spectralis 和 Topcon 对 3 个带的评分者间一致性较高（κ=0.876、0.738 和 0.774）。每种仪器对 ELM 带（0.92、0.98 和 0.96）、第二带（均为 1.00）和第三带（0.96、0.94 和 0.88）的敏感性均较高。与 Cirrus、Spectralis 和 Topcon 相比，Topcon 对第三带的敏感性显著低于第二带（Fisher 确切检验，P=0.027），但与其他仪器之间的差异无统计学意义。机器间一致性对于第三带（κ=0.65、0.512 和 0.464）和所有带（κ=0.531、0.369 和 0.362）在 Cirrus-Spectralis、Spectralis-Topcon 和 Topcon-Cirrus 之间为尚可至中度；然而，在 Spectralis-Topcon 之间，ELM 带的一致性无统计学意义（κ=-0.027）。
在视力正常的健康成年人中，Cirrus、Spectralis 和 Topcon 设备采集的黄斑微结构图像的评分者间几乎具有完美的可重复性。这些仪器对黄斑微结构成像具有良好的敏感性，且敏感性在各仪器间无显著差异；然而，它们对于成像某些结构不一定是完全相同或可互换的。
