Klinikum Fulda gAG, Department of Pharmacy, Pacelliallee 4, Fulda, Germany.
Clin Appl Thromb Hemost. 2012 Jun;18(3):299-304. doi: 10.1177/1076029611412368. Epub 2011 Jul 6.
Despite the existence of antithrombotic guidelines, there is low compliance with these guidelines in clinical practice. Until now pharmacy interns (PIs) have not been involved in this process. The objectives were to involve PIs to evaluate compliance with antithrombotic guidelines for VTE prophylaxis in surgery patients, and in cases of noncompliance to carry out pharmaceutical interventions. The study was conducted in 7 hospitals in Germany involving 27 PIs within the project "Pharmacy interns on the ward" (P-STAT 2). Pharmacy interns determined the thromboembolic risk, documented antithrombotic medication, and checked the compliance with current antithrombotic guidelines. A total of 6491 patients were enrolled; 5695 patients received antithrombotic prophylaxis. Antithrombotic guideline was followed in 77.5% patients. Many patients are not receiving appropriate VTE prophylaxis or heparin bridging regimen despite the fact that evidence-based antithrombotic guidelines are available. Pharmacy interns may play an important role in antithrombotic management.
尽管存在抗血栓治疗指南，但在临床实践中，这些指南的遵从率很低。到目前为止，实习药剂师（PIs）并未参与这一过程。本研究的目的是让实习药剂师参与评估手术患者预防静脉血栓栓塞症（VTE）的抗血栓治疗指南的遵从情况，并在不遵从的情况下进行药物干预。该研究在德国的 7 家医院进行，涉及“病房实习药剂师”（P-STAT 2）项目中的 27 名实习药剂师。实习药剂师确定血栓栓塞风险，记录抗血栓药物，并检查与当前抗血栓治疗指南的遵从情况。共纳入 6491 例患者；5695 例患者接受了抗血栓预防治疗。77.5%的患者遵从了抗血栓治疗指南。尽管有循证抗血栓治疗指南，但许多患者并未接受适当的 VTE 预防治疗或肝素桥接治疗方案。实习药剂师可能在抗血栓治疗管理中发挥重要作用。
