General Surgery, Ankara University Medical School, Ankara, Turkey.
Clin Appl Thromb Hemost. 2012 Jan-Feb;18(1):40-4. doi: 10.1177/1076029611412369. Epub 2011 Jul 6.
Factor V Leiden (FVL) is the most common inherited risk factor for venous thromboembolism (VTE). The frequency of FVL in patients with VTE has been reported from different parts of Turkey. A meta-analysis was performed to estimate the risk of VTE associated with FVL in Turkish population. Published studies were retrieved from Pubmed and Science Citation Index/Expanded. We selected studies comparing the prevalence of FVL in patients with VTE with controls. The analysis was performed by the software comprehensive meta-analysis. The analysis consisted of 10 studies including 1202 patients with VTE and 1283 controls. The pooled frequency of FVL was significantly higher in patients with VTE (22.8%) than controls (7.6%). The pooled odds ratio (OR) was 3.4 (95% confidence interval [CI], 2.6-4.5). The study showed homogeneity (Q value, 9.955). No publication bias was observed in any comparison model. Our meta-analysis showed an association of FVL with VTE in Turkey.
因子 V 莱顿（FVL）是静脉血栓栓塞症（VTE）最常见的遗传性危险因素。FVL 在土耳其不同地区 VTE 患者中的频率已有报道。进行了一项荟萃分析，以评估 FVL 与土耳其人群 VTE 相关的风险。从 Pubmed 和科学引文索引/扩展版检索已发表的研究。我们选择了比较 VTE 患者和对照组中 FVL 患病率的研究。使用综合荟萃分析软件进行分析。该分析包括 10 项研究，共纳入 1202 例 VTE 患者和 1283 例对照组。VTE 患者中 FVL 的总频率明显高于对照组（22.8% vs. 7.6%）。合并优势比（OR）为 3.4（95%置信区间[CI]，2.6-4.5）。该研究显示具有同质性（Q 值为 9.955）。在任何比较模型中均未观察到发表偏倚。我们的荟萃分析显示 FVL 与土耳其的 VTE 之间存在关联。
