牛疱疹病毒4型在人细胞中的体外复制
Replication of bovine herpesvirus type 4 in human cells in vitro.
作者信息
Egyed L
机构信息
Veterinary Medical Research Institute of the Hungarian Academy of Sciences, Budapest.
出版信息
J Clin Microbiol. 1998 Jul;36(7):2109-11. doi: 10.1128/JCM.36.7.2109-2111.1998.
Abstract
A reference strain (Movár 33/63) of bovine herpesvirus type 4 (BHV-4) was inoculated into 14 different human cell lines and five primary cell cultures representing various human tissues. BHV-4 replicated in two embryonic lung cell lines, MRC-5 and Wistar-38, and in a giant-cell glioblastoma cell culture. Cytopathic effect and intranuclear inclusion bodies were observed in these cells. PCR detected a 10,000-times-higher level of BHV-4 DNA. Titration of the supernatant indicated a 100-fold increase of infectious particles. Since this is the first bovine (human herpesvirus 8 and Epstein-Barr virus related) herpesvirus which replicates on human cells in vitro, the danger of possible human BHV-4 infection should not be ignored.
摘要
将牛疱疹病毒4型（BHV - 4）的一株参考毒株（Movár 33/63）接种到14种不同的人类细胞系和5种代表不同人体组织的原代细胞培养物中。BHV - 4在两种胚胎肺细胞系MRC - 5和Wistar - 38以及一种巨细胞胶质母细胞瘤细胞培养物中复制。在这些细胞中观察到细胞病变效应和核内包涵体。PCR检测到BHV - 4 DNA水平高出10000倍。对上清液进行滴定表明感染性颗粒增加了100倍。由于这是第一种（与人类疱疹病毒8型和爱泼斯坦 - 巴尔病毒相关的）能在体外人类细胞上复制的牛疱疹病毒，因此不能忽视人类可能感染BHV - 4的危险。
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