B 淋巴细胞谱系特异性、早期 B 细胞因子 1 的承诺和转录的表观遗传控制。
B lymphocyte lineage specification, commitment and epigenetic control of transcription by early B cell factor 1.
机构信息
Department of Immunology, University of Colorado School of Medicine, Denver, CO 80206, USA.
出版信息
Curr Top Microbiol Immunol. 2012;356:17-38. doi: 10.1007/82_2011_139.
Abstract
Early B cell factor 1 (EBF1) is a transcription factor that is critical for both B lymphopoiesis and B cell function. EBF1 is a requisite component of the B lymphocyte transcriptional network and is essential for B lineage specification. Recent studies revealed roles for EBF1 in B cell commitment. EBF1 binds its target genes via a DNA-binding domain including a unique 'zinc knuckle', which mediates a novel mode of DNA recognition. Chromatin immunoprecipitation of EBF1 in pro-B cells defined hundreds of new, as well as previously identified, target genes. Notably, expression of the pre-B cell receptor (pre-BCR), BCR and PI3K/Akt/mTOR signaling pathways is controlled by EBF1. In this review, we highlight these current developments and explore how EBF1 functions as a tissue-specific regulator of chromatin structure at B cell-specific genes.
摘要
早期 B 细胞因子 1（EBF1）是一种转录因子，对 B 淋巴细胞发生和 B 细胞功能至关重要。EBF1 是 B 淋巴细胞转录网络的必需组成部分，对于 B 细胞谱系的特化是必需的。最近的研究揭示了 EBF1 在 B 细胞承诺中的作用。EBF1 通过一个 DNA 结合结构域（包括一个独特的“锌指”）与其靶基因结合，该结构域介导一种新的 DNA 识别模式。在原 B 细胞中，通过染色质免疫沉淀法确定了数百个新的以及先前鉴定的靶基因。值得注意的是，前 B 细胞受体（pre-BCR）、BCR 和 PI3K/Akt/mTOR 信号通路的表达受 EBF1 控制。在这篇综述中，我们强调了这些最新进展，并探讨了 EBF1 如何作为组织特异性的 B 细胞特异性基因染色质结构调节剂发挥作用。
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