基因-基因相互作用分析
Analysis of gene-gene interactions.
作者信息
Gilbert-Diamond Diane, Moore Jason H
机构信息
Computational Genetics Laboratory, Departments of Genetics and Community and Family Medicine, Dartmouth Medical School, Lebanon, New Hampshire, USA.
出版信息
Curr Protoc Hum Genet. 2011 Jul;Chapter 1:Unit1.14. doi: 10.1002/0471142905.hg0114s70.
Abstract
The goal of this unit is to introduce gene-gene interactions (epistasis) as a significant complicating factor in the search for disease susceptibility genes. This unit begins with an overview of gene-gene interactions and why they are likely to be common. Then, it reviews several statistical and computational methods for detecting and characterizing genes with effects that are dependent on other genes. The focus of this unit is genetic association studies of discrete and quantitative traits because most of the methods for detecting gene-gene interactions have been developed specifically for these study designs.
摘要
本单元的目标是介绍基因-基因相互作用（上位性），它是寻找疾病易感基因过程中的一个重要复杂因素。本单元首先概述基因-基因相互作用以及它们可能普遍存在的原因。然后，回顾几种用于检测和表征其效应依赖于其他基因的基因的统计和计算方法。本单元的重点是离散性状和数量性状的遗传关联研究，因为大多数检测基因-基因相互作用的方法都是专门针对这些研究设计开发的。
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